Effect of gestational weight gain on colonization of neonatal gut microbiota

JIANG Zi-han; LU Wen-wei; SHI Hui-jing; WEI Qian; ZHANG Yun-hui; WANG Ling

doi:10.11852/zgetbjzz2019-1084

PDF(1334 KB)

Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (10) : 1072-1076. DOI: 10.11852/zgetbjzz2019-1084

Effect of gestational weight gain on colonization of neonatal gut microbiota

JIANG Zi-han¹, LU Wen-wei², SHI Hui-jing¹, WEI Qian¹, ZHANG Yun-hui¹, WANG Ling¹

Author information +

History +

Abstract

Objective To understand alpha diversity and composition of neonatal gut microbiota and to explore the effect of gestational weight gain on neonatal gut microbiota acqusition. Methods The study was based on a prospective birth cohort.Totally 323 pregnant women with complete pregnancy follow-up information recruited in the cohort between April 2016 and February 2017 were randomly selected, and meconium of their babies after delivering were collected.16S rDNA gene sequencing was performed on the meconium samples.The sequence of 207 samples where bacteria exit were analyzed.According to the gestational weight gain standard of American Institute of Medicine, the subjects were divided into two groups:non-excessive gestational weight gain(n=129) and excessive gestational weight gain(n=78). Results Gestational weight gain influences the abundance of neonatal gut microbiota.Compared with the group of non-excessive gestational weight gain, the neonatal intestinal Proteobacteria was higher(P<0.05)and Parabacteroides was lower(P<0.05)in group of excessive gestational weight gain.Gestational weight gain was negatively related to Shannon index(β=-0.378,P=0.013;β=-0.502,P=0.041)and Simpson index(β=-0.055,P=0.012;β=-0.073,P=0.039)by adjusting pre-pregnancy BMI, delivery mode, parity, gestational age, antibiotic exposure and stratified by neonatal gender. Conclusion Excessive gestational weight gain influences the composition of neonatal intestinal microbiota and decreases the alpha diversity of gut microbiota of male neonates.

Key words

gestational weight gain / neonate / meconium / gut microbiota

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

JIANG Zi-han, LU Wen-wei, SHI Hui-jing, WEI Qian, ZHANG Yun-hui, WANG Ling. Effect of gestational weight gain on colonization of neonatal gut microbiota[J]. Chinese Journal of Child Health Care. 2020, 28(10): 1072-1076 https://doi.org/10.11852/zgetbjzz2019-1084

References

[1] 杨慧霞,段涛.健康与疾病的发育起源——DOHaD在中国[M].北京:人民卫生出版社,2013.
[2] Collado MC, Rautava S, Aakko J, et al.Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid[J].Sci Rep,2016,6:23129.
[3] Jimenez E, Fernandez L, Marin ML, et al.Isolation of commensal bacteria from umbilical cord blood of healthy neonates born by cesarean section[J].Curr Microbiol,2005,51(4):270-274.
[4] Lim ES, Zhou Y, Zhao G, et al.Early life dynamics of the human gut virome and bacterial microbiome in infants[J].Nat Med,2015,21(10):1228-1234.
[5] Stiemsma LT, Michels KB.The role of the microbiome in the developmental origins of health and disease[J].Pediatrics,2018,141(4):e20172437.
[6] Goldstein RF, Abell SK, Ranasinha S, et al.Association of gestational weight gain with maternal and infant outcomes:a systematic review and meta-analysis[J].JAMA,2017,317(21):2207-2225.
[7] Collado MC, Isolauri E, Laitinen K, et al.Effect of mother′s weight on infant′s microbiota acquisition, composition, and activity during early infancy:a prospective follow-up study initiated in early pregnancy[J].Am J Clin Nutr,2010,92(5):1023-1030.
[8] 檀丽薇, 史慧静, 王英, 等.上海地区孕早中期孕妇睡眠质量现况及相关的社会结构性因素[J].上海预防医学,2018,30(3):207-211.
[9] Kominiarek MA, Peaceman AM.Gestational weight gain[J].Am J Obstet Gynecol,2017,217(6):642-651.
[10] Institute of Medicine(US) and National Research Council(US) Committee to Reexamine IOM Pregnancy Weight Guidelines.Rasmussen KM, Yaktine AL.Weight gain during pregnancy:reexamining the guidelines[M].Washington(DC):National Academies Press(US),2009.
[11] Mclnnes P, Cutting M.Core microbiome sampling protocol A HMP Protocol # 07-001.Manual of procedures[J].Hum Microbiome Proj,2010,11:1-109.
[12] 席晓霞.初生婴儿肠道菌群与母体各部位菌群相关性研究[D].呼和浩特:内蒙古农业大学,2017.
[13] Landman C, Quevrain E.Gut microbiota:Description, role and pathophysiologic implications[J].Rev Med Interne,2016,37(6):418-423.
[14] Caicedo RA, Schanler RJ, Li N, et al.The developing intestinal ecosystem:implications for the neonate[J].Pediatr Research,2005,58(4):625.
[15] Mueller NT, Shin H, Pizoni A, et al.Birth mode-dependent association between pre-pregnancy maternal weight status and the neonatal intestinal microbiome[J].Sci Rep,2016,6:23133.
[16] Stanislawski MA, Dabelea D, Wagner BD, et al.Pre-pregnancy weight, gestational weight gain, and the gut microbiota of mothers and their infants[J].Microbiome,2017,5(1):113.
[17] Stewart CJ, Ajami NJ, O′Brien JL, et al.Temporal development of the gut microbiome in early childhood from the TEDDY study[J].Nature,2018,562(7728):583-588.
[18] Koleva PT, Tun HM, Konya T, et al.Sex-specific impact of asthma during pregnancy on infant gut microbiota[J].Eur Respir J,2017,50(5):1700280.
[19] 李菊芳, 姜铁民, 贾妮, 等.分娩方式及性别对母乳喂养婴儿肠道菌群的影响[J].中国妇幼健康研究,2017,28(9):1035-1040.
[20] Kozyrskyj AL, Kalu R, Koleva PT, et al.Fetal programming of overweight through the microbiome:boys are disproportionately affected[J].J Dev Orig Health Dis,2016,7(1):25-34.
[21] Stanislawski MA, Dabelea D, Wagner BD, et al.Gut microbiota in the first 2 years of life and the association with body mass index at age 12 in a Norwegian birth cohort[J].MBio,2018,9(5):e01751-18.