Objective To analyze the effect of amplitude integrated electroencephalography (EEG) on brain function monitoring in neonates with brain injury,in order to provide scientific evidence for clinical treatment of neonatal brain injury. Methods A total of 60 full-term infants with fetal distress were selected as the observation group from February 2017 to January 2019,and 60 healthy infants in the same period were selected as control group. Subjects were monitored by amplitude-integrated EEG. Amplitude integrated EEG abnormalities,graphs, the normal sleep arousal cycle status and epileptiform activity were recorded in the two groups. The amplitude and narrowband voltage values of the amplitude of the integrated EEG background activity of the two groups were compared. The relationship between abnormal amplitude integrated EEG pattern and imaging was compared;Relationship between the neuronal behavior and neurological specific protein in children with abnormal amplitude integrated EEG were evaluated. Results The abnormal rate of amplitude integrated EEG in the observation group was 8. 33%,significantly higher than that in control group (0. 0%) (χ2=5. 217,P=0. 022). The rate of normal sleep arousal cycle in the observation group was significantly lower than that in the control group (90. 0% vs. 100. 0%,χ2=6. 316,P=0. 011). No epileptiform activity was observed in the control group,but 1 case occurred in the observation group. Of the 5 children with amplitude-enhanced EEG abnormalities,3 had normal head B examination,MRI showed subarachnoid hemorrhage in 1 case,1 had discontinuous normal voltage with abnormal sleep arousal cycle,accompanied by epileptiform activity,and 3 patients with neurobehavioral assessment were lagged behind and the rest were normal. The NSE and S-100 in the observation group were significantly higher than those in control group,and the NSE and S-100 in children with abnormal amplitude-integrated EEG were significantly higher than those in children with normal amplitude-enlarged EEG (F=8. 751,6. 325,P<0. 01). Conclusions Amplitude-integrated EEG has a high value in monitoring of brain function in neonates with brain injury. It can better judge the condition of children and is of great value of guiding clinical diagnosis and treatment.
Key words
amplitude integratedelectroencephalography /
brain function /
monitoring /
neonates /
brain injury
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References
[1] 傅勇,王克煊.振幅整合脑电图与新生儿脑功能监测[J].中国儿童保健杂志,2016,24(8):835-837.
[2] 邱锐琴,吴小波,夏明月,等.新生儿振幅整合脑电图对评估早产儿脑功能发育状态的临床应用价值[J].河北医学,2019,25(4):617-622.
[3] 张称,郝丽红.振幅整合脑电图在新生儿缺氧缺血性脑病中的应用价值[J].中国初级卫生保健,2017,31(4):30-31.
[4] 王维,李佳,王立利,等.振幅整合脑电图与磁共振成像对儿童病毒性脑炎急性期诊断及预后的评估价值分析[J].实用心脑肺血管病杂志,2019,27(2):81-84.
[5] 马娟,陈龙,薛颖,等.振幅整合脑电图在新生儿窒息早期诊断和预后评估中的临床价值[J].重庆医学,2017,46(15):2037-2038.
[6] 罗惠玲,白波,黄暖潮,等.持续脑功能监测在新生儿缺氧缺血性脑病早期诊断中的应用效果[J].中国当代医药,2019,26(7):137-139.
[7] 沈佩婷,黄金华,温晓红,等.振幅整合脑电图对早产儿脑白质损伤的早期诊断及近期神经发育预后评估的应用价值[J].中国妇幼保健,2019,34(4):942-945.
[8] 邱锐琴,吴小波,夏明月,等.持续脑功能监测在新生儿脑损伤早期诊断及预后评价中的应用[J].贵州医药,2019,43(1):126-128.
[9] 蒋丽军,吴明赴,张龙峰.血清乳酸水平与振幅整合脑电图在新生儿窒息中的临床研究[J].中国中西医结合儿科学,2018,10(6):523-527.
[10] 高亮,林新祝,吴倩倩,等.振幅整合脑电图对急性胆红素脑病不良预后的预测价值[J].中国妇幼保健,2018,33(23):5631-5634.
[11] 王云,杨冬,周彬.振幅整合脑电图用于重度高胆红素血症新生儿健康状况和智力发育水平评估的价值[J].解放军预防医学杂志,2018,36(11):1438-1440.
[12] 羊玲,钟丽花,陈彩华.不同胎龄早产儿振幅整合脑电图的特点分析[J].蚌埠医学院学报,2018,43(11):1428-1430.
[13] 谢士笛,张海鸿,万彬,等.动态观察枸橼酸咖啡因治疗原发性早产儿呼吸暂停的脑电活动变化[J].山东医药,2018,58(42):46-48.
[14] 徐文慧,刘娜娜,彭斯聪,等.振幅整合脑电图评分系统在胎龄≤32周早产儿脑发育评估中的应用及评价[J].南昌大学学报:医学版,2018,58(5):40-46.
[15] 吴玉帆,苏鸿辉,苏华泽,等.振幅整合脑电图对脑损伤新生儿脑功能监测的临床应用[J].现代医院,2018,18(10):1539-1541.
[16] 张树英,曾贵祥,陈海华,等.振幅脑电图联合头颅超声检查预测超低或极低出生体重早产儿神经系统发育结局的效果[J].广西医学,2018,40(16):1889-1891.
[17] 严衍庆,蔡嘉伟,方文华,等.探讨振幅整合脑电图对高分级动脉瘤性蛛网膜下腔出血患者预后的预测作用[J].中华神经创伤外科电子杂志,2018,4(4):201-204.
[18] 郭燕,陆焰,孙晓娟.延续性护理对昏迷患儿严重程度的影响研究[J].中国现代医生,2018,56(20):158-160,164.
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