Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects

WEI Hong; SONG Xi-yuan; LIU Xue; CAO Hui-ling; KONG Ling-ling; WANG Xu

doi:10.11852/zgetbjzz2019-1022

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (7) : 774-779. DOI: 10.11852/zgetbjzz2019-1022

Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects

WEI Hong, SONG Xi-yuan, LIU Xue, CAO Hui-ling, KONG Ling-ling, WANG Xu

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Abstract

Objective To systematically evaluate associations between gene polymorphism of maternal and offsprings' reduced folate carrier (RFC1) A80G and the risk of neural tube defects (NTDs),so as to provide evidence for the prevention of NTDs. Methods Case-control study on the correlation between RFC1 A80G polymorphism of maternal and /or offspring' with NTDs were searched in CBM,CNKI,Wan-Fang Data,Pubmed,Embase and Cochrane Library from establishment of the database to May 2019.And RevMan 5.3 software was used to analyze data. Results 1) There was significant association between maternal RFC1 A80G polymorphism and increasing risk of NTDs in Asia (GG vs.AA:OR=4.13,95%CI:1.97―8.67;GA vs.AA:OR=3.03,95%CI:1.72―5.32;GG+GA vs.AA:OR=3.25,95%CI:1.90―5.56;G vs.A:OR=1.94,95%CI:1.15―3.28).2) There was significant association between offsprings' RFC1 A80G poly morphism and increasing risk of NTDs in Asia (GG vs.AA:OR=2.20,95%CI:1.34―3.63;GG+GA vs.AA:OR=1.58,95%CI:1.02―2.46;GG vs.GA+AA:OR=1.89,95%CI:1.31―2.72;G vs.A:OR=1.55,95%CI:1.21―1.98). Conclusion Both maternal and offsprings' RFC1 A80G polymorphism are risk factors of NTDs in Asian population.

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neural tube defects / gene polymorphism / reduction folate carrier gene / Meta-analysis

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WEI Hong, SONG Xi-yuan, LIU Xue, CAO Hui-ling, KONG Ling-ling, WANG Xu. Meta-analysis on the associations of reduced folate carrier A80G polymorphism with neural tube defects[J]. Chinese Journal of Child Health Care. 2020, 28(7): 774-779 https://doi.org/10.11852/zgetbjzz2019-1022

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