Objective To compare the prognosis of simple family rehabilitation training and family rehabilitation training combined with medicine intervention in high-risk infants with normal general movements (GMs) assessment, in order to analyze the guidance significance of GMs on the early intervention of high-risk infants. Methods A total of 183 high-risk infants with normal GMs assessment were recruited at the Rehabilitation Department of Weifang Maternal and Child Health Hospital from February 2016 to February 2017.Infants were randomly assigned to observation group and control group.The observation group (n=89) received simple family rehabilitation training, whereas the control group received family rehabilitation training combined with medicinal interventions (n=94).Infants were assessed at corrected age of 6,9 and 12 months using the Peabody Development Motor Scales (PDMS).Statistical analysis of measurements of the PDMS was performed with SPSS 21.0. Results After intervention, there was no significant difference on the scores of gross movement quotient (GMQ), fine motor quotient (FMQ), and total sports quotient (TMQ) between observation group and control group at the corrected age of 6,9 and 12 months (P>0.05).Repeated analysis of variance showed that the difference on the GMQ, FMQ, and TMQ scores between observation group and control group was not significant (P>0.05), while the time influence on the GMQ, FMQ, and TMQ scores was significant(P<0.05).There were no interactions between the effect of family rehabilitation training combined with medicinal interventions and time on the GMQ, FMQ, and TMQ scores (P>0.05). Conclusions GMs assessment is of great guiding significance for the early intervention of high-risk infants.For high-risk infants with normal GMs assessment results, family rehabilitation without medicinal interventions may well be as effective as that with medicinal interventions, so excessive intervention should be avoided.