Objective To explore the rehabilitation effect of the Learning Style Profile(LSP) on children with autism spectrum disorder(ASD),in order to promote its application in China. Methods A total of 55 ASD children aged 36-72 months were admitted from June 2018 to June 2019,trained with LSP for 6 months and evaluated to assess rehabilitation effect by 0 to 6-year-old Children′s Neuropsychological Development Scale,Childhood Autism Rating Scale(CARS) and Strengths and Difficulties Questionnaire(SDQ) before and after intervention. Results According to the results of 0 to 6-year-old Children′s Neuropsychological Development Scale,developmental quotient(DQ) of language expression, social behavior and adaptive behavior area were significantly improved after intervention (t=7.99,7.10,6.29,P＜0.01), while DQ of large motor and fine motor area were improved without significant difference(t=1.28,1.76,P>0.05).Meanwhile,the score of CARS scale was significantly decreased after intervention(t=6.36,P＜0.01).According to the results of SDQ scale,hyperactivity attention deficit score,peer relationship score and difficulty score were significantly decreased,pro-social behavior score was significantly improved(t=5.98,6.96,7.74,6.78,P＜0.01).Emotional symptom score and conduct problems score were decreased without significant difference(t=0.24,0.92,P>0.05). Conclusionss LSP can effectively improve the social skills and reduce the severity of symptoms in children with ASD.So LSP can be more widely used in the treatment of ASD children in China.