Objective To study the therapeutic efficacy and intellectual influence of levetiracetam on children with benign epilepsy with central-sacral spine,so as to provide scientific evidence for clinical treatment. Methods Totally 60 children with central pox epilepsy who underwent central fossa from August 2016 to July 2018 were enrolled in the study.All subjects were randomly divided into control group (n=30) and observation group (n=30) according to the envelope method.The control group was treated with carbamazepine,while the observation group was treated with levetiracetam.The clinical efficacy,P300 latency,intelligence level,visual and auditory attention,and adverse reaction rate were compared between the two groups. Results After treatment,the total clinical effective rate of the observation group was higher than that of the control group (96.67% vs.73.33%,P＜0.05).The incubation period of P300 was shorter than that of the control group,and the difference was statistically significant(t=3.527, P＜0.05).The language IQ,operational IQ,total IQ,the control quotient and attention quotient of visual stimulation and auditory stimulation in the observation group were higher than those in control group (t=9.186,2.347,3.143,2.113,4.171,2.052,3.592,P＜0.05).In terms of the incidence of adverse reactions,no significant difference was found between the two groups (P＞0.05). Conclusion Levetiracetam treatment can effectively control seizures in children with benign epilepsy with central-sacral region,and has a positive effect on P300 latency and intelligence level.