Research progress on the mechanism of gut microbiota participating in airway hyperresponsiveness of allergic asthma through short-chain fatty acids

HE Xue-jia; ZHU Wei-wei; BI Mei-rong

doi:10.11852/zgetbjzz2019-0803

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (4) : 431-434. DOI: 10.11852/zgetbjzz2019-0803

Research progress on the mechanism of gut microbiota participating in airway hyperresponsiveness of allergic asthma through short-chain fatty acids

HE Xue-jia^{1, 2}, ZHU Wei-wei², BI Mei-rong²

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Abstract

Bronchial asthma (asthma) is a chronic airway inflammatory disease characterized by reversible airflow obstruction and airway hyperresponsiveness.Short-chain fatty acids (SCFAs),as the products of indigestible carbohydrates such as dietary fiber and resistant starch produced by intestinal probiotics,are not only the important energy source for the body,but also important immune signal molecules.The increasing concentration of SCFAs in the blood plays a protective role in pulmonary allergic inflammation.A large number of studies have shown that the occurrence of asthma is closely related to the changes of intestinal flora.This paper summarizes the possible molecular mechanism of intestinal flora participating in asthma airway hyperresponsiveness through short-chain fatty acids from the three aspects of ERK1/2 signaling pathway,TGF-β1/Smads signaling pathway,and GPR41 and GPR43 expression,thereby providing a potential new target for the treatment of asthma.

Key words

bronchial asthma / intestinal flora / short-chain fatty acids / airway hyperresponsiveness / signaling pathway

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HE Xue-jia, ZHU Wei-wei, BI Mei-rong. Research progress on the mechanism of gut microbiota participating in airway hyperresponsiveness of allergic asthma through short-chain fatty acids[J]. Chinese Journal of Child Health Care. 2020, 28(4): 431-434 https://doi.org/10.11852/zgetbjzz2019-0803

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