Objective To analysis the serum 25-hydroxyvitamin D level and lymphocyte subsets in neonates with community acquired pneumonia,and to provide evidence for clinical treament. Methods A total of 68 full-term neonates diagnosed with community acquired pneumonia in the First People′s Hospital of Yongkang City from November 2018 to January 2019 were randomly selected as the observation group,and 68 healthy full-term neonates born in the same period of our hospital as the control group.Serum 25-hydroxyvitamin D level was detected by BIO-RAD 680 ELISA and lymphocyte subsets were detected by Facs Canto2 flow cytometry of BD company. Results Compared with the control group,the serum 25-hydroxyvitamin D level in the observation group was significantly lower than that in the control group (t=6.815,P＜0.01).The positive rate of CD3+ and CD4+ cells and the ratio of CD4+/CD8+ in the observation group were significantly lower than those in the control group (t=2.912,2.947,3.115,P＜0.01); the positive rate of CD19+ cells in the observation group was significantly higher than that in the control group (t=5.565, P＜0.01).The positive rates of CD3+ and CD4 + cells,CD4+/CD8+ in the 25-hydroxyvitamin D deficiency group were significantly lower than those in the normal group (t=3.084,4.234,3.021,P＜0.01); but the positive rates of CD19+ cells in the deficient group was significantly higher than that in the normal group (t=3.515, P＜0.01). Conclusionss The incidence of 25-hydroxyvitamin D deficiency in neonates with community-acquired pneumonia is higher.The level of cellular immunity in neonates with community-acquired pneumonia is lower,which may be related to the low level of 25-vitamin D.
Key words
community acquired pneumonia /
25-hydroxyvitamin D /
lymphocyte subsets /
xellular immunity /
neonates
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 陈鸿羽,邓春.新生儿社区和院内获得性肺炎的病原学特点及药敏分析[J].临床儿科杂志, 2016,34(7):510-514.
[2] Hua W,Jun T,Ying X,et al.Neonatal community-acquired pneumonia:pathogens and treatment[J].J Paediatr Child Health,2010,46(11):668-672.
[3] 中华医学会儿科学分会儿童保健学组.儿童微量营养素缺乏防治建议[J].中华儿科杂志,2010,48(7):502-509.
[4] 温慧敏,闫向真,刘新建,等.新生儿社区获得性肺炎感染病原菌分布及其耐药性分析[J].实用预防医学,2015,22(1):108-109.
[5] Cetinkaya M,Cekmez F,Buyukkale G,et al.Lower vitamin D levels are associated with increased risk of early-onset neonatal sepsis in term infants[J].J Perinatol,2015,35(1):39.
[6] Mulrennan S,Knuiman M,Walsh JP,et al.Vitamin D and respiratory health in the Busselton Healthy Ageing Study[J].Respirology,2018,20(Suppl 60):49.
[7] Martineau AR,Jolliffe DA,Hooper RL,et al.Vitamin D supplementation to prevent acute respiratory tract infections:systematic review and meta-analysis of individual participant data[J].BMJ,2017,356.doi:10.1136/bmj.16583.
[8] Jovanovich AJ,Ginde AA,John H,et al.Vitamin D level and risk of community-acquired pneumonia and sepsis[J].Nutrients,2014,6(6):2196-2205.
[9] Larkin A,Lassetter J.Vitamin D deficiency and acute lower respiratory infections in children younger than 5 years:identification and treatment[J].J Child Health Care,2014,28(6):572-582.
[10] Sakka ASE,Imam SS,Amer HA,et al.Vitamin D deficiency and low hemoglobin level as risk factors for severity of acute lower respiratory tract infections in Egyptian children:A case-control study[J].Gaz Egypt Paediatr Assoc,2014,62(1):1-7.
[11] Rich RR,Fleisher TA,Shearer WT,et al.Clinical immunology:principles and practice[M].5th.Oxford:Elsevier Limited,2019:183-196.
[12] Vasiliou JE,Lui S,Walker SA,et al.Vitamin D deficiency induces Th2 skewing and eosinophilia in neonatal allergic airways disease[J].Allergy,2014,69(10):1380-1389.
[13] Goldsmith J.Vitamin D as an immunomodulator:Risks with deficiencies and benefits of supplementation[J].Healthcare,2015,3(2):219-232.
[14] Hornsby E,Pfeffer PE,Laranjo N,et al.Vitamin D supplementation during pregnancy:Effect on the neonatal immune system in a randomized controlled trial[J].J Allergy Clin Immunol,2018,141(1):269-278.
[15] K1l1caslan AÖ,Kutlu R,Kilinc I,et al.The effects of vitamin D supplementation during pregnancy and maternal vitamin D levels on neonatal citamin D levels and birth parameters[J].J Matern Fetal Neonatal Med,2017,31(13):1727-1734.
PDF(463 KB)
