Clinical analysis of vitamin D and respiratory distress syndrome in preterm infants

GENG Jia-qing; FANG Cheng-zhi; ZHANG Bing-hong

doi:10.11852/zgetbjzz2019-0725

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (3) : 345-348. DOI: 10.11852/zgetbjzz2019-0725

Clinical analysis of vitamin D and respiratory distress syndrome in preterm infants

GENG Jia-qing, FANG Cheng-zhi, ZHANG Bing-hong

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Abstract

Objective To analyze the relationship between serum vitamin D [25- (OH)D₃] levels at birth and respiratory distress syndrome (RDS) in preterm infants,in order to provide scientific basis for the treatment of RDS in preterm infant. Methods A total of 131 premature infants with RDS admitted to the Wuhan University People′s Hospital were selected as the experimental group,and 29 non-RDS premature infants were used as control group.The clinical data (such as gender,mode of delivery,maternal pregnancy and Apgar score)and the results of serum 25- (OH) D₃ were collected,and the association between serum 25- (OH)D₃ level and RDS was analyzed. Results 25- (OH)D₃ levels in the RDS group was lower than that in control group (t=2.682,P＜0.05),and CPAP time,oxygen therapy days,intravenous nutrition days,hospitalization time were significantly longer than those in control group (t=2.969,2.380,2.571,1.999,P＜0.05).Binary logistic regression analysis showed that vitamin D deficiency was risk factors for RDS in preterm infants (OR=0.050,95%CI:0.013-0.186). Conclusions Preterm infants with low vitamin D level may increase the incidence of RDS.So it is of great significance for prevention of vitamin D deficiency.

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vitamin D / neonatal respiratory distress syndrome / preterm infant

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GENG Jia-qing, FANG Cheng-zhi, ZHANG Bing-hong. Clinical analysis of vitamin D and respiratory distress syndrome in preterm infants[J]. Chinese Journal of Child Health Care. 2020, 28(3): 345-348 https://doi.org/10.11852/zgetbjzz2019-0725

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