Study on 25-hydroxy vitamin D level in short stature children with different growth hormone secretion status

CHEN Jin; TAO Lin-hui; LIN Ai-lin; LIN Yun

doi:10.11852/zgetbjzz2019-0570

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (2) : 219-221. DOI: 10.11852/zgetbjzz2019-0570

Study on 25-hydroxy vitamin D level in short stature children with different growth hormone secretion status

CHEN Jin, TAO Lin-hui, LIN Ai-lin, LIN Yun

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Abstract

Objective To study the levels of 25-hydroxy vitamin D[25-(OH)D] in short stature children with different growth hormone secretion status, So as to provide theoretical basis for clinicl evaluation. Method Totally 101 children with short stature treated in the department of pediatrics of Taizhou Municiple Hospital from June 2017 to December 2018 were enrolled in this study.and were divided into completely growth hormone deficiency(CGHD)group,part growth hormone deficiency(PGHD)group and idiopathic short stature(ISS)group according to the peak value of growth hormone drug stimulation test.Meanwhile,20 children of normal height were randomly selected as control group.Serum25-(OH)D levels of each group were determined by chemiluminescence. Result Among the 101 children,there were 26 cases in the CGHD group,37 cases in the PGHD group and 38 cases in the ISS group.Levels of 25-(OH)D in the three groups were all significantly lower than those in normal group(P<0.01),and the levels of 25-(OH)D in the CGHD group were significantly lower than those in the PGHD and ISS groups(P<0.05).The incidence rates of vitamin D deficiency and insufficiency in the CGHD,PGHD and ISS groups were higher thanthose in the normal group (P<0.01),and there was no significant difference among the CGHD,PGHD and ISS three groups (P>0.05). Conclusions The level of 25-(OH)D in short stature children with different growth hormone secretion status decreases in different degrees,especially in CGHD group.

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short stature / growth hormone / growth hormone deficiency / 25-hydroxy vitamin D

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CHEN Jin, TAO Lin-hui, LIN Ai-lin, LIN Yun. Study on 25-hydroxy vitamin D level in short stature children with different growth hormone secretion status[J]. Chinese Journal of Child Health Care. 2020, 28(2): 219-221 https://doi.org/10.11852/zgetbjzz2019-0570

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