Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants

WANG Jing; ZHANG Yue; TAN Mei-zhen; XIAO Yu-lian; WEI Ru; WANG Ling-hua

doi:10.11852/zgetbjzz2019-0497

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (10) : 1115-1119. DOI: 10.11852/zgetbjzz2019-0497

Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants

WANG Jing¹, ZHANG Yue², TAN Mei-zhen¹, XIAO Yu-lian¹, WEI Ru¹, WANG Ling-hua³

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Abstract

Objective To analyze the relationship between cord blood 25-hydroxyvitamin D [25-(OH)D] and infant atopic dermatitis(AD),in order to provide reference for the primary prevention and early intervention for AD in infants. Methods Totally 202 mothers and their infants were enrolled in this study from December 2016 to December 2017.Cord blood was collected at birth,and the children were followed up to 6 months old.A standard questionnaire was used to obtain the information of parents and infants,serum level of cord blood 25-(OH)D was detected by enzyme-linked immunosorbent assay.Objective Scoring of Atopic Dermatitis(SCORAD) was used to assess the severity of AD in infants.And the risk factors for AD in infants were analyzed by nested case-control study and Logistic regression analyzed. Results There was no statistically significant difference on cord blood level of 25-(OH)D between AD group and the healthy control group .Positive family history of allergy (OR=1.963),non-exclusive breastfeeding (OR=2.089),and birth in summer (OR=2.265) were risk factors for the occurrence of AD(P＜0.05).Cord blood levels of 25-(OH)D was negatively correlated with the severity of AD in infants (r=-0.325,P=0.023). Conclusions Cord blood 25-(OH)D can not predict the occurrence of AD in infants,but it is negatively correlated with the severity of AD.Reasonable vitamin D supplementation during pregnancy may reduce the severity of AD in infants.

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cord blood / 25-hydroxyvitamin D / atopic dermatitis / infant

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WANG Jing, ZHANG Yue, TAN Mei-zhen, XIAO Yu-lian, WEI Ru, WANG Ling-hua. Relationship between cord blood 25-hydroxyvitamin D and atopic dermatitis within 6 months after birth in infants[J]. Chinese Journal of Child Health Care. 2019, 27(10): 1115-1119 https://doi.org/10.11852/zgetbjzz2019-0497

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