Objective To compare the effect of inhaled fluticasone propionate with a spacer and atomization inhalation budesonide suspension on the prognosis of children with acute bronchiolitis. Methods A total of 187 infants diagnosed with bronchiolitis in Tongzhou Maternal and Child Health Hospital of Beijing from September 2016 to June 2018 were enrolled in this study and were randomly divided into fluticasone treatment group(67 cases),budesonide treatment group(63 cases) and control group(57 cases).Fluticasone treatment group received inhaled fluticasone propionate with a spacer,budesonide treatment group was given atomization inhalation budesonide suspension,and the infants in control group did not receive any inhalation of corticosteroids after hospital discharge.All children were followed up for 1 month,and lung function and the fractional exhaled nitric oxide(FeNO),the recurrent wheezing times were compared before and after the follow-up. Results The number of children who completed follow-up in fluticasone treatment group,budesonide treatment group and control group was 67,62 and 56 cases,respectively.After the intervention,the ratio of time to peak tidal expiratory flow to total expiratory time(TPTEF/TE) and ratio of volume to peak expiratory flow to total expiratory volume(VPEF/VE) were significantly higher than those before intervention(P<0.05),but the FeNO was significantly lower than that before intervention(P<0.05).The number of children with recurrent wheezing in the two groups was significantly lower than that in the control group,but the difference was not significant(P>0.05). Conclusions Inhaled fluticasone propionate can effectively prevent and treat the relapse of cough and wheezing after bronchiolitis in the short term,reduce the airway inflammation and improve the lung function.The way of inhale corticosteroid with a spacer is so handy that it can replace aerosol inhalation to improve the prognosis of bronchiolitis.