Objective To investigate the efficacy of three antiepileptic drugs on epilepsy,including valproic acid,oxcarbazepine and levetiracetam,and to analyze their effects on bone metabolism of children with school-age children. Methods A total of 150 school-age children with epilepsy admitted to Baoding Children′s Hospital were enrolled in this study from June 2015 to June 2018,and were randomly divided into three groups,with 50 cases in each group.Group A received oxcarbazepine,group B received levetiracetam,while group C was given valproic acid for monotherapy.After 6 months of treatment,the efficacy of three drugs was evaluated.The changes in bone metabolic markers before and after intervention were compared. Results After treatment,the levels of Ca and 25- (OH) D in group A significantly decreased,while ALP level significantly increased (t=21.125,4.037,4.976,P＜0.001).ALP level in group B was significantly higher after treatment (t=2.321,P＜0.05).Moreover,the levels of Ca,25- (OH)D and BMD in group C significantly decreased after treatment,while the levels of ALP and BAP significantly increased after treatment (t=31.596,5.991,3.591,3.239,4.643,P＜0.001).The total effective rates of three groups were significantly different (P＜0.05). Conclusions For children with epilepsy,the efficacy of levetiracetam is superior to that of valproic acid,and the adverse reaction of levetiracetam is less than oxcarbazepine.It is worth noting that levetiracetam has the least impact on bone metabolism indicators in school-age children.Because of its safety and effectiveness,levetiracetam is worth of clinical application.