Analysis of thalassemia gene detection in children attending physical examination in Chengdu area

YU Xia; LIU Cheng-gui; SHEN Wei; YANG Lian; LIAO Zhi-yong; LIU Rui; ZHU Jing

doi:10.11852/zgetbjzz2019-0227

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (12) : 1339-1341. DOI: 10.11852/zgetbjzz2019-0227

Analysis of thalassemia gene detection in children attending physical examination in Chengdu area

YU Xia^1,2, LIU Cheng-gui¹, SHEN Wei¹, YANG Lian¹, LIAO Zhi-yong¹, LIU Rui¹,ZHU Jing²

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Abstract

Objective To analyze the gene carrying rate and genotype of thalassemia in children undergoing physical examination in Chengdu,so as to provide basis for formulating preventive measures against thalassemia in this area. Methods A retrospective analysis was made on the results of blood routine test and thalassemia gene test in 8 327 children who underwent nursery examination in Chengdu Women & Children's Central Hospital from January 2017 to June 2018. Results A total of 423 cases(5.07%) of small cell hypochromic anemia were detected in 8 327 children.And 158 cases(1.90%) were diagnosed with thalassemia by gene testing,of which 64 cases(40.51%) were diagnosed with alpha-thalassemia,with the highest detection rate of --^SEA/αα(29.75%).And 94 cases(59.49%) were diagnosed with beta-thalassemia,with the highest detection rate of CD41/42(-TCTT)(34.18%). Conclusion Prevention and control of thalassemia in Chengdu mainly focus on preventing the birth of Parkinson's edema fetus and severe beta-thalassemia children,and take corresponding measures to reduce the carrying rate of thalassemia.

Key words

thalassemia / genotype / physical examination

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YU Xia, LIU Cheng-gui, SHEN Wei, YANG Lian, LIAO Zhi-yong, LIU Rui,ZHU Jing. Analysis of thalassemia gene detection in children attending physical examination in Chengdu area[J]. Chinese Journal of Child Health Care. 2019, 27(12): 1339-1341 https://doi.org/10.11852/zgetbjzz2019-0227

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