Correlative study on body mass index with sex hormone,leptin and adiponectin in girls with central precocious puberty

ZHANG Jian; ZHOU Hong-juan; GAO Jin-ping; ZHAO Qin

doi:10.11852/zgetbjzz2019-0201

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (2) : 187-190. DOI: 10.11852/zgetbjzz2019-0201

Correlative study on body mass index with sex hormone,leptin and adiponectin in girls with central precocious puberty

ZHANG Jian, ZHOU Hong-juan, GAO Jin-ping, ZHAO Qin

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Abstract

Objective To investigate the effects of body mass index (BMI) on serum levels of sex hormones,leptin and adiponectin(APN) in girls with central precocious puberty,in order to provide reference for appropriately analyzing GnRHa test result and illustrating the possible mechanism of leptin and adiponectin in adolescent development of obese children. Methods Totally 90 cases of idiopathic central precocious puberty girls who completed the gonadotropin-releasing hormone analogue (GnRHa) test in the Affiliated Zhangjiagang Hospital of Soochow University from 2016 to 2018 were selected.According to body mass index (BMI),the participants were divided into normal weight group (n=40),overweight group (n=30) and obesity group (n=20).Serum levels of follicle stimulating hormone (FSH),luteinizing hormone (LH),estradiol (E₂),testosterone (T),leptin,APN were tested.The correlations between BMI and various hormone levels were analyzed by Spearman correlation analysis. Results The peaks of LH and APN in the overweight and obesity groups were significantly lower than those in the normal group (P<0.05),which was also significantly lower in obesity group than those in overweight group (P<0.05). The leptin level in the overweight group and obesity group was significantly higher than that in normal group (P<0.05).Moreover,obesity group had significantly higher levels of leptin than overweight group (P<0.05).There were positive correlations between BMI and E₂,T and leptin levels (r=0.213,0.250,0.484,P<0.05),and had negative correlations with LH peak and APN levels (r=-0.417,-0.525,P<0.05). Conclusion It is supposed to take BMI into account when analyzing the result of the GnRHa agonist test and the levels of obesity-related hormones in girls with precocious puberty.

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body mass index / obesity / leptin / adiponectin / precocious puberty

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ZHANG Jian, ZHOU Hong-juan, GAO Jin-ping, ZHAO Qin. Correlative study on body mass index with sex hormone,leptin and adiponectin in girls with central precocious puberty[J]. Chinese Journal of Child Health Care. 2020, 28(2): 187-190 https://doi.org/10.11852/zgetbjzz2019-0201

References

[1] Xu L,Lam TH.Stage of obesity epidemic model:Learning from tobacco control and advocacy for a framework convention on obesity control[J].Diabetes,2018,10(7):564-571.
[2] Zhao YL,Ma RM,LaoTT,et al.Maternal gestational diabetes mellitus and overweight and obesity in offspring:a study in Chinese children[J].Dev Orin Health Dis,2015,6(6):479-484.
[3] 周雪莲,傅君芬,吴蔚,等.肥胖对中枢性性早熟女童 GnRH 激发试验促黄体生成素峰值及相关激素的影响 [J].中国当代儿科杂志,2015,17(8):763-767.
[4] Prodam F,Roccio M,Trovato L,et al.Adiponectin oligomers are similarly distributed in adequate-for-gestational-age obese children irrespective of feeding in their first year [J].Pediatr Res,2015,77(6):808-813.
[5] 中华医学会儿科学分会内分泌遗传代谢学组,《中华儿科杂志》编辑委员会.中枢性性早熟诊断与治疗共识 (2015) [J].中华儿科杂志,2015,53(6):412-418.
[6] 李辉,宗心南,季成叶等.中国2～18岁儿童青少年超重和肥胖筛查体重指数界值点的研究[J].中华流行病学杂志,2010,31(6):616-620.
[7] Collins JS,Beller JP,Burt Solorzano C.Blunted day-night changes in luteinizing hormone pulse frequency in girls with obesity:The potential role of hyperandrogenemia [J].Clin Endocrinol Metab,2014,99(8):2887-2896.
[8] Lee HY,Lee YJ,Ahn MB,et al.The effect of overweight on the luteinizing hormone level after gonadorelin stimulation test in girls with idiopathic central precocious puberty[J].Ann Pediatr Endocrinol Metab,2018,23(4):215-219.
[9] Pinkney J,Streeter A,Hosking J,et al.Adiposity,chronic inflammation,and theprepubertal decline of sex hormone binding globulin in children:evidence for associations with the timing of puberty (Earlybird 58)[J].Clin Endocrinol Metab,2014,99(9):3224-3232.
[10] Pilia S,Casini MR,Foschini ML,et al.The effect of puberty on insulin resistance in obese children[J].Endocrinol Invest,2009,32(5):401-405.
[11] Sliwowska JH,Fergani C,Gawałek M,et al.Insulin:its role in the central control of reproduction[J].Physiol Behav,2014,133:197-206.
[12] Leggio A,Catalano S,de Marco R,et al.Therapeutic potential of leptin receptor modulators[J].Eur J Med Chem,2014,78:97-105.
[13] Berglund E.D,Vianna C.R,Donato J,et al.Direct leptin action on POMC neurons regulates glucose homeostasis and hepatic insulin sensitivity in mice[J].Clin Investig,2012,122(3):1000-1009.
[14] Philbrick KA,Wong CP,Branscum AJ,et al.Leptin stimulates bone formation in ob/ob mice at doses having minimal impact on energy metabolism[J].Endocrinol,2017,232(3):461-474.
[15] Francisco V,Ruiz-Fernández C,Pino J,et al.Adipokines:linking metabolic syndrome,the immune system,and arthritic diseases[J].Biochem Pharmacol,2019,2952(19):30116-30119.
[16] Kang MJ,Oh YJ,Shim YS,etal.The usefulness of circulating levels of leptin,kisspeptin,and neurokinin B in obese girls with precocious puberty[J].Gynecol Endocrinol,2018,34(7):627-630.
[17] Awede B,Adovoekpe D,Adehan G,et al.Adiponectin,in contrast to leptin,is not associated with body mass index,waist circumference and HOMA-IR in subjects of a west-African population[J].Physiol Rep,2018,6(11):13718.
[18] Liu M,Liu F.Regulation ofadiponectin multimerization,signaling and function[J].Best Pract Res Clin Endocrinol Metab,2014,28(1):25-31.
[19] Maggio MC,Montaperto D,Maringhini S,et al.Adiponectin,resistin and leptin in paediatric chronic renal failure:correlation with auxological and endocrine profiles[J].Nephrol,2014,27(3):275-279.
[20] Ghomari-Boukhatem H,Bouchouicha A,Mekki K,et al.Blood pressure,dyslipidemia and inflammatory factors are related to body mass index in scholar adolescents[J].Arch Med Sci,2017,13(1):46-52.
[21] Khabour OF,Alomari MA,Abu Obaid AA.The Relationship of adiponectin level and ADIPOQ gene variants with BMI among young adult women[J].Dermatoendocrinol,2018,10(1):1477902.
[22] Massaro M,Scoditti E,Pellegrino M,et al.Therapeutic potential of the dual peroxisome proliferator activated receptor (PPAR)α/γ agonist aleglitazar in attenuating TNF-α-mediated inflammation and insulin resistance in human adipocytes[J].Pharmacol Res,2016,107:125-136.
[23] Forouhi N,Saedisomeolia A,Djalali M,et al.Serum C1q and tumor necrosis factor (TNF)-related protein 9 in women with polycystic ovary syndrome[J].Diabetes Metab Syndr,2016,10(2):131-134.
[24] Lee B,ShaoJ.Adiponectin and energy homeostasis[J].Rev Endocr Metab Disord,2014,15(2):149-156.
[25] Boyraz M,Cekmez F,Karaoglu A,et al.Serum adiponectin,leptin,resistin and RBP4 levels in obese and metabolic syndrome children with nonalcoholic fatty liver disease[J].Biomark Med,2013,7(5):737-745.