Objective To investigate the percentage of T lymphocyte subsets and its value in predicting the development of wheezing in infants experiencing their early episodes of wheezing in infants and young children with mycoplasma pneumonia(MP) infection complicated with wheezing,so as to provide scientific evidence for clinical treatment. Methods A total of 200 cases with positive result of MP antibody in the Department of Pediatrics,Weifang People′s Hospital were enrolled in this study as MP infection group from May to November 2017,of whom 92 wheezing cases with MP infection were in MP wheezing group,and 108 cases with MP infection but without wheezing were in MP non-wheezing group.Meanwhile,89 cases with acute bronchial asthma were selected as asthma group.The percentage of peripheral blood T cell subsets in three groups was measured,and 92 cases in MP wheezing group were in followed up for one year.Results 1) After one-year follow-up,70 cases were with recurrent wheezing,17 cases were without wheezing,and 5 cases lost in follow-up.2) MP wheezing group and MP non-wheezing group had significantly more percentage of CD3+CD4+ and CD3+CD4+/CD3+CD8+lymphocytesthan the asthma group,lower percentage of CD3-CD19+ lymphocytes than the asthma (P＜0.05).3) After one-year follow-up in MP wheezing group,the percentages of CD3+CD4+ and CD3+CD4+/CD3+CD8+ lymphocytes in recurrent wheezing group were significantly lower than those in non-wheezing group,and the percentage of CD3-CD19+ lymphocytes was significantly higher than that in non-wheezing group(P＜0.01). Conclusions 1) There is imbalance of T lymphocyte subsets in infants and young children with MP infection complicated by wheezing. 2) Infants and young children with MP infection complicated by wheezing, with lower percentage of CD3+CD4+/CD3+CD8+ lymphocytes, are prone to resulting in recurrent wheezing and even developing asthma.
Key words
mycoplasma pneumoniae /
asthma /
T lymphocyte subsets /
wheezing /
infant and young child
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