Objective To understand the immune status of children born to hepatitis B virus(HBV)-infected mothersin Changsha,so as to further provide evidence for formulating interventions. Methods Mother to child blocking of HBV was conducted in infants born to permanent HBV-infected mothers in Changsha from April 1st,2017 to September 30th,2018.After finishing hepatitis B vaccination at the age of 0,1 and 6 months,the levels of surface antigen,surface antibody,E antigen,E antibody and core antibody of hepatitis B were tested. Results The injection rate of hepatitis B immunoglobulin in children born to HBV-infected mothersin Changsha was 99.9%(6 492/6 498).And 1 533 children conducted related indexes of hepatitis B.It was found that the rate of mother-to-child transmission of hepatitis B was 1.44 %,and the positive conversion rate of hepatitis B surface antibodies was 80.8%,with significant difference between urban and rural areas(χ²=7.022,32.497,P＜0.05). Conclusions The prevention of mother-to-child transmission of HBV in Changsha has achieved remarkable results.Government is supposed to establish a regular monitoring information mechanism for HBV exposure,so that some children who have successfully blocked the prevention of hepatitis B surface antibodies without developing hepatitis B surface antibodies can be immunized in a timely manner,thereby avoiding infection,and further reducing the regional hepatitis B infection rate.