Objective To analyze the role of brain-strengthening and intelligence-benefiting acupuncture combined with sensory integration training in children of cerebral palsy with mental retardation,So as to provide scientific evidence for clinical treatment. Methods A total of 184 children with cerebral palsy and mental retardation admitted to Hunan Children′s Hospital from November 2015 to March 2018 were randomly divided into A,B,C and D group,with 46 cases in each group.Group A received routine rehabilitation training,and group B and C were given sensory integration training,and brain-strengthening and intelligence-benefiting acupuncture additionally.While the group D was given routine rehabilitation,brain-strengthening and intelligence-benefiting acupuncture treatment combined with sensory integration training. The scores of developmental quotient (DQ),intelligence quotient (IQ),Children Sensory Integration Rating Scale (CSIRS) and Infants-junior and Middle School Students Social-life Ability Scale were compared,and the occurrence of adverse events was observed. Results The scores of DQ,IQ,CSIRS and Infants-Junior and Middle School Students Social-Life Ability Scale of the 4 groups after treatment were higher than those before treatment,with significant differences (t=2.234,4.157,4.019,7.281,3.782,5.499,5.263,8.002,5.519,7.988,8.121,11.756,11.591,23.327,24.886,39.339,5.305,8.013,8.113,11.490,P＜0.05 or <0.01),and the scores of DQ,IQ,CSIRS and Infants-Junior and Middle School Students Social-Life ability Scale of the group D after treatment were higher than group B,C and A,with significant differences (t=2.579,2.821,4.439,2.108,2.282,3.849,3.176,3.352,5.758,19.829,17.666,33.204,2.863,3.053,5.305,P＜0.05 or 0.01). There was no significant difference on the incidence rates of total adverse events among the 4 groups (χ²=0.748,P=0.852). Conclusion Brain-strengthening and intelligence-benefiting acupuncture combined with sensory integration training can significantly improve the DQ and IQ of children of cerebral palsy with mental retardation,as well as their sensory integration ability and social life ability with good safety.