Objectives To investigate the relationship between serum betatrophin and growth development among fetus,in order to provide reference for fetal healthcare. Methods Totally 30 large for gestational age(LGA)infants,30 appropriate for gestational age(AGA) infants and 30 small for gestational age(SGA) infants were enrolled in this study in Maternal and Child Health Hospital of Ruian People′s Hospital from January to July 2018. Serum betatrophin level in cord blood,maternal blood and amniotic fluid was tested,and the relationships among betatrophin in cord blood,indexes of fetal growth and development,glucose and lipid metabolic parameters,insulin resistance,leptin and serum adiponectin were analyzed. Results The serum betatrophin levels in cord blood of LGA,AGA and SGA were (1 009.210±98.761) ng/L,(929.487±80.949) ng/L and (910.590±105.518) ng/L respectively,with significant difference among three groups(F=8.986,P<0.001). There were no significant differences on lipid indexes among LGA,AGA and SGA infants(P>0.05). Pearson correlation analysis indicated that serum betatrophin level in cord blood was positively correlated with birth weight,ponderal index(PI) and gestational age of neonates,leptin and triglyceride(TG) in cord blood(r=0.537,0.502,0.250,0.422,0.832,P<0.05),and negative correlation was found between serum betatrophin and adiponectin level in cord blood(r=-0.257,P<0.05).However,there were no significant correlations between serum betatrophin level and betatrophin level in maternal blood or amniotic fluid,body weight before pregnancy and delivery,pre-pregnancy BMI,BMI increase during pregnancy,placental weight,plasma glucose(PG),insulin(INS) and HOMA-IR in cord and maternal blood(P>0.05). Multivariate linear regression analysis showed that blood betatrophin was an independently influencing factor for neonatal birth weight(P＜0.05). Conclusions Betatrophin level of cord blood is related to the adjustment of fetal growth. On the other hand,betatrophin level can reflect the status of feta1 growth and development.
Key words
betatrophin /
fetus /
blood lipid /
ponderal index /
cord blood
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