Objective To understand the etiology,clinical features and therapeutic management of children with chronic wet cough in Qingdao area,in order to provide clinical basis for standardization and normalization of the diagnosis and treatment of chronic wet cough. Methods According to the 2013 Guidelines for diagnosis and treatment of chronic cough in children revised by Chinese Medical Association,726 children diagnosed with chronic wet cough in Cough and Asthma Clinic of Qingdao Women and Children's Hospital were selected from July 2017 to July 2018.The data were statistically analyzed and the constituent ratio of causes and treatment of chronic cough were obtained. Results 1) The leading 5 causes of chronic wet cough in 726 children included upper airway cough syndrome(UACS,47.1%),post-infectious cough(PIC,24.7%),protracted bacterial bronchitis(PBB,7.85%),asthma with infection(6.74%) and gastroesophageal reflux cough(GERC,5.23%).2) The etiological composition in children at different age groups was different,and the onset time,appearance of sputum and cytological analysis were different.3) The correction rate of main diagnosis and multiple causes was as high as 55.55%,mainly with combined treatment.Combined treatment of 3 to 4 drugs in the first visit accounted for 45.31%. Conclusions 1) The etiology of chronic wet cough in children in Qingdao is different from that of chronic cough.2) Because of the lack of standardized management and high proportion of modified diagnosis,more attention should be paid to the clinical efficacy of chronic wet cough.In addition,for cases with more causes and unknown etiology,it is necessary for clinical staff to give more concern,revise the diagnosis and adjust the medication timely according to the principles of observation and follow-up.