Objective To analyze the clinical value of swallowing function training and non-nutritive sucking treatment in extremely premature infants,in order to provide evidence for clinical intervention.Methods Totally 100 cases of extremely premature infants in Neonatal Intensive Care Unit (NICU) of Changzhou Maternal and Child Health Hospital were enrolled in this study from January 2016 to August 2017. According to the random non-blind method of grouping, infants were divided into two groups, with 50 cases in ead group. The control group took traditional oral feedings, while the intervention group received swallowing function training combined with non-nutritive sucking. The feeding situation, fasting time, oral gastric nutrition time, average hospitalization days and total enteral feeding for gestational age and other indicators of the two groups were analyzed and compared.Results The cases of good feeding performance in intervention group (46, 92.0%) were significantly more than those in control group (31, 62.0%)(P<0.05). The fasting time, the nutrition time of nasogastric tube, the average hospitalization day and the age of the full mouth feeding in intervention group were significantly shorter than those in control group(all P＜0.05).Conclusion Swallowing function training on extremely premature infants and non-nutritive sucking can help premature establish the swallowing sucking reflex, improve oral feeding conditions, and promote the rehabilitation so that it is worthy of popularization and application.