Meta-analysis of the influencing factors for birth defects in China from 2008 to 2018

CAO Li-li; WAN Li; QIAN Ting

doi:10.11852/zgetbjzz2018-26-11-15

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (11) : 1217-1220. DOI: 10.11852/zgetbjzz2018-26-11-15

Meta-analysis of the influencing factors for birth defects in China from 2008 to 2018

CAO Li-li, WAN Li, QIAN Ting

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Abstract

Objective To explore the main risk factors related to birth defects, in order to provide scientific evidence for preventing birth defects.Methods Meta-analysis was performed to quantitatively review case-control studies of risk factors for the birth defects since 2008 to 2018.Results Multi-factor analysis combined with effect quantity estimation results showed that family history, mother′s smoking, father′s smoking, exposure to teratogenic factors during pregnancy, environmental pollution sources, adverse pregnancy and childbirth history, early pregnancy illness, mood disorders, and drug use were risk factors. While premarital examination, pregnancy examination, folic acid supplementation, and regular intake of high quality protein during pregnancy were protective factors.Conclusions Pregnant women are suggested to avoid prenatal exposure to various physical and chemical harmful substances, attach importance to routine marriage and pregnancy tests, and establish a healthy lifestyle. Also, more high quality protein and folic acid supplementation during pregnancy is crucial to improve physical fieness.

Key words

birth defects / influencing factors / Meta-analysis

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CAO Li-li, WAN Li, QIAN Ting. Meta-analysis of the influencing factors for birth defects in China from 2008 to 2018[J]. Chinese Journal of Child Health Care. 2018, 26(11): 1217-1220 https://doi.org/10.11852/zgetbjzz2018-26-11-15

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