Research progress on the influencing factors and related pathogenesis mechanism of neural tube defects

JIANG Chun-qian; LI Yan-ping; GUO Shuang; SONG Ying-dong; XU Ding

doi:10.11852/zgetbjzz2018-26-11-10

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (11) : 1199-1202. DOI: 10.11852/zgetbjzz2018-26-11-10

Research progress on the influencing factors and related pathogenesis mechanism of neural tube defects

JIANG Chun-qian¹, LI Yan-ping¹, GUO Shuang², SONG Ying-dong¹, XU Ding¹

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Abstract

Neural tube defects (NTDs) are severe congenital malformations that originated in the process of embryogenesis, and are the result of an abnormal process of neural tube closure. NTDs are caused by multiple factors, including genetic factors, environmental factors, and the interaction between genetics and the environment. Folic acid supplementation may reduce the incidence, but the mechanism is not yet clear, and the occurrence of NTDs is also related to other factors. This review summarizes research progress on the factors associated with NTDs and the related pathogenesis mechanism.

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neural tube defects / gene / environment / mechanism / research progress

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JIANG Chun-qian, LI Yan-ping, GUO Shuang, SONG Ying-dong, XU Ding. Research progress on the influencing factors and related pathogenesis mechanism of neural tube defects[J]. Chinese Journal of Child Health Care. 2018, 26(11): 1199-1202 https://doi.org/10.11852/zgetbjzz2018-26-11-10

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