Objective To assess the effect of colostrum as oral immune therapy on clinical outcomes in very low birth weight preterm infants, in order to provide evidence for the treatment of preterm infants.Methods Totally 89 preterm infants with very low birth weight in the Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University from January 2015 to December 2016 were enrolled in this study, and were divided into oral immune therapy group(n=59) and control group(n=30). Participants received colostrums or normal saline via oropharyngeal route for 3 days. Clinical data during hospitalization and prognostic indicators were collected and analyzed.Results The incidence of clinical sepsis was 8.5% in the oral immune therapy group, significantly lower than that in control group (26.7%)(P＜0.05). However, there were no significant differences on the incidence rates of proven sepsis, necrotizing enterocolitis (NEC), retinopathy of prematurity (ROP), periventricular-intraventricular hemorrhage (PIVH) and bronchopulmonary dysplasia (BPD), hospitalization days, body weight at discharge and clinical prognosis(all P＞0.05).Conclusion Colostrum as oral immune therapy can reduce the incidence of clinical sepsis, but not reduce the incidence rates of proven sepsis, NEC, ROP, PIVH and BPD.
Key words
colostrum /
oral immune therapy /
very low birth weight /
preterm infants
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