Research on the association between ApoE genotype and global developmental delay

LIU Li-li; YANG Lin; WANG Qiong; CHEN Xiao-cong; MA Ying-ge

doi:10.11852/zgetbjzz2018-26-10-10

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (10) : 1081-1083. DOI: 10.11852/zgetbjzz2018-26-10-10

Research on the association between ApoE genotype and global developmental delay

LIU Li-li¹, YANG Lin², WANG Qiong¹, CHEN Xiao-cong¹, MA Ying-ge¹

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Abstract

Objective To investigate the correlation between ApoE allele frequencies and generalized developmental delay(GDD) in children,in order to provide an effective way of etiological prevention,early diagnosis and intervention for children with GDD . Method Isolation and purification of DNA from peripheral blood,PCR amplication and Hha I digestion for the distribution of genotyping of ApoE were used to test the ApoE genotypes of 66 GDD children (GDD group) and 50 normal children (control group).Also,the correlation between ApoE allele frequencies and GDD was analyzed. Result The ApoEε4 allele frequency of GDD group was significantly higher than that of control group(χ² =5.05,P＜0.05). Conclusions The high frequency of ApoEε4 is associated with GDD,meantime it may be a genetic susceptibility factor for GDD children.

Key words

generalized developmental delay / apolipoprotein E / allelic genes

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LIU Li-li, YANG Lin, WANG Qiong, CHEN Xiao-cong, MA Ying-ge. Research on the association between ApoE genotype and global developmental delay[J]. Chinese Journal of Child Health Care. 2018, 26(10): 1081-1083 https://doi.org/10.11852/zgetbjzz2018-26-10-10

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