Objective To study the relationship between bone mineral density (BMD) and plasma lipid profiles in infants aged 6~12 months,in order to provide guidance for prevention and treatment of osteoporosis in infants. Methods Totally 164 individuals aged 6~12 months were randomly selected from infants undergoing regular physical examination in Maternal and Children's Health Care Hospital of Sanshui District from July 2015 to July 2016. Ultrasound BMD detection and plasma lipid tests were administrated. And participants were divided into 4 groups according to the results of ultrasound BMD, including 30 infants of normal BMD, 50 infants of mild BMD deficiency, 50 infants of moderate BMD deficiency, and 34 infants of severe BMD deficiency. The body length, weight and lipids profiles were compared among all groups. Pearson correlation test was used to analyze the correlation between Z value of BMD and age, body weight, body length, and blood lipid levels. Results There were significant differences on body length, low density lipoprotein-cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) levels in infants among the four groups. Among them, TG level was significantly lower in group with abnormal BMD than in normal group. Pearson correlation analysis showed that Z value of BMD was positively correlated with male gender, age, body length, body weight, TC, LDL-C and TG levels (all P<0.05). Multi-linear regression revealed that TG remained significantly correlated with BMD Z value (β=0.549, P=0.002) after adjusted for age, gender, body weight, body length and TC. Conclusions The level of BMD in infants and young children is closely related to blood lipid levels and body length. So controlling the intake of saturated fatty acids rationally is of great significance to the growth and development as well as osteoporosis prevention in infants.
Key words
bone mineral density /
plasma lipid profiles /
infant
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Sun H, Ma Y, Han D, et al. Prevalence and trends in obesity among China's children and adolescents, 1985-2010[J]. PLoS One,2014,9(8):e105469.
[2] Nelson RH. Hyperlipidemia as a risk factor for cardiovascular disease[J]. Prim Care,2013,40(1):195-211.
[3] Qu X, Huang X, Jin F, et al. Bone mineral density and all-cause, cardiovascular and stroke mortality: a meta-analysis of prospective cohort studies[J]. Int J Cardiol,2013,166(2):385-393.
[4] Veronese N, Stubbs B, Crepaldi G, et al. Relationship between low bone mineral density and fractures with incident cardiovascular disease: a systematic review andmeta-analysis[J]. J Bone Miner Res,2017,32(5):1126-1135.
[5] 莫娟,吴静,雷闽湘,等.肥胖儿童骨密度变化及其影响因素分析[J]. 中国实用儿科杂志,2009,24(3):187-189.
[6] Palermo A, Tuccinardi D, Defeudis G, et al. BMI and BMD: The potential interplay between obesity and bone fragility[J]. Int J Environ Res Public Health, 2016,13(6):544.
[7] Gállego Suarez C, Singer BH, Gebremariam A, et al. The relationship between adiposity and bone density in U.S. children and adolescents[J]. PLoS One,2017,12(7):e0181587.
[8] Frost ML, Blake GM, Fogelman I. Quantitative ultrasound and bone mineral density are equally strongly associated with risk factors for osteoporosis[J]. J Bone Miner Res,2001,16(2):406-416.
[9] Solomon DH, Avorn J, Canning CF, et al. Lipid levels and bone mineral density[J]. Am J Med,2005,118(12):1414.
[10] Soininen S, Sidoroff V, Lindi V, et al. Body fat mass, lean body mass and associated biomarkers as determinants of bone mineral density in children 6~8 years of age-The Physical Activity and Nutrition in Children (PANIC) study[J]. Bone,2018,108,106-114.
[11] Makovey J, Chen JS, Hayward C, et al. Association between serum cholesterol and bone mineral density[J]. Bone,2009,44(2):208-213.
[12] Dennison EM, Syddall HE, Aihie Sayer A, et al. Lipid profile, obesity and bone mineral density: the hertfordshire cohort study[J]. QJM,2007,100(5):297-303.
[13] Park SW, Nam GE, Jung DW, et al. Association of lipid parameters and insulin resistance with bone health in South Korean adolescents[J].Osteoporos Int,2016,27(2):635-642.
[14] 廖 新,穆亚平.5～7岁低体重和肥胖儿童身体成分特点及脂肪肌肉含量与骨密度相关性研究[J].中国实用儿科杂志,2016,31(4):301-304.
[15] Turner CH, Forwood MR, Rho JY, et al. Mechanical loading thresholds for lamellar and woven bone formation[J]. J Bone Miner Res,1994,9(1):87-97.
[16] 谭振朝. 婴幼儿骨密度及其影响因素分析[J]. 中国妇幼保健,2012,27(25):3931-3932.
[17] 刘燕,符丽,周帆.0～3岁婴幼儿骨密度与体格发育指标相关性分析[J]. 湖南师范大学学报:医学版,2017,14(1):78-80.
PDF(745 KB)
