Meta-analysis of caesarean section may increase the risk of childhood allergic diseases

HU Fang; LU Jian-jun; HU Yan; XING Yan-fei; JIANG Lin; LIU Hui-yan; MA Ying; LIN Sui-fang

doi:10.11852/zgetbjzz2018-26-09-15

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (9) : 985-990. DOI: 10.11852/zgetbjzz2018-26-09-15

Meta-analysis of caesarean section may increase the risk of childhood allergic diseases

HU Fang¹, LU Jian-jun², HU Yan¹, XING Yan-fei¹, JIANG Lin¹, LIU Hui-yan¹, MA Ying¹, LIN Sui-fang¹

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Abstract

Objective To analyze the correlation between caesarean section and allergic diseases in childhood by conducting a meta-analysis, in order to provide evidence for the prevention of childhood allergic diseases. Methods Literatures published till 5th September, 2017 were searched in five databases, and were retrieved, filtered, incorporated and analyzed according to the preset standard.Meta-analysis was performed by using Rev Man 5.3 software.The corresponding effect model was selected according to the heterogeneity results and subgroup analysis was performed. Results Totally 63 studies were included, the sample size was 4 818 347.Compared with natural birth, caesarean section significantly increased the risks of having asthma, food allergy, allergic conjunctivitis, inhalation allergy, wheezing and hay fever in children by 19%, 31%, 14%, 29%, 4% and 16%, respectively(P＜0.05).Subgroup analysis showed that cesarean section did not increase the risk of asthma in children under 3 years old, while other subgroups were statistically significant (P<0.05).Caesarean section was associated with children's wheezing among the subgroups of cohort study(OR=1.05,95%CI:1.01～1.08),questionnaire(parents reported symptoms)(OR=1.07,95%CI:1.01～1.14)and parents without allergic diseases(OR=1.05, 95%CI:1.00～1.10). Conclusion Caesarean section increases the risk of allergic diseases in childhood, so it is necessary to strengthen maternal health education and obstetric management to guarantee healthy life of children.

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caesarean section / allergic disease / children / Meta-analysis

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HU Fang, LU Jian-jun, HU Yan, XING Yan-fei, JIANG Lin, LIU Hui-yan, MA Ying, LIN Sui-fang. Meta-analysis of caesarean section may increase the risk of childhood allergic diseases[J]. Chinese Journal of Child Health Care. 2018, 26(9): 985-990 https://doi.org/10.11852/zgetbjzz2018-26-09-15

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