Study on hydrogen sulfide and 25-(OH)D3 in obese children with different glucose tolerance

ZHANG Yuan-da; LIU Yu; ZHANG Yu; LIU Rui-hua; BAI Lu; DONG Qing-wei; SONG Hao-bin; HAN Li-po

doi:10.11852/zgetbjzz2018-26-09-08

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (9) : 956-959. DOI: 10.11852/zgetbjzz2018-26-09-08

Study on hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance

ZHANG Yuan-da¹, LIU Yu², ZHANG Yu¹, LIU Rui-hua³, BAI Lu⁴,DONG Qing-wei¹, SONG Hao-bin¹,HAN Li-po¹

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Abstract

Objective To study the significance of changes of serum hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance. Methods According to the oral glucose tolerance test(OGTT),204 obese children were divided into impaired fasting glycaemia(IFG) group,impaired glucose tolerance (IGT) group,IFG combined with IGT group and diabetes mellitus(DM) group from Jan 2013 to Jan 2016. Totally 46 obese children with normal OGTT were as obese group. The levels of serum H₂S and 25-(OH)D₃ were tested by spectrophotometer and euzymelinked immunosorbent assay(ELISA) respectively. Results The levels of H₂S and 25-(OH)D₃ were lowest in obese group (P＜0.05);The levels of H₂S and 25-(OH)D₃ were lower in IFG combined with IGT group than IFG group and IGT group (P＜0.05);The levels of H₂S and 25-(OH)D₃ were lower in DM group than those of IFG group,IGT group and IFG combined with IGT group(P＜0.05); The levels of H₂S and 25-(OH)D₃ were lower in IFG group than IGT group(P＜0.05). The levels of H₂S and 25-(OH)D₃ were lower in DM group than obese group (P＜0.05); The levels of H₂S and 25-(OH)D₃ were lower in IFG combined with IGT group than obese group and IGT group (P＜0.05).The levels of serum H₂S and 25-(OH)D₃ was negatively correlated with 0 h PG,2 h PG and HBALC (P<0.05). The level of serum H₂S was positively correlated with 25-(OH)D₃(P<0.05). Conclusion Serum levels of H₂S and 25-(OH)D₃ are closely associated with glucose tolerance in obese children and it may develop into a risk factor when the levels decrease obviously.

Key words

diabetes mellitus type 2 / H₂S / 25-(OH)D₃

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ZHANG Yuan-da, LIU Yu, ZHANG Yu, LIU Rui-hua, BAI Lu,DONG Qing-wei, SONG Hao-bin,HAN Li-po. Study on hydrogen sulfide and 25-(OH)D₃ in obese children with different glucose tolerance[J]. Chinese Journal of Child Health Care. 2018, 26(9): 956-959 https://doi.org/10.11852/zgetbjzz2018-26-09-08

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