Objective To evaluate the associations between omentin-1 and childhood non-alcoholic fatty liver disease (NAFLD). Methods A total of 116 obese children were divided into NAFLD with obesity (n=61) and without obesity(n=55) group, and 55 children with normal weight were as control. The height, weight, waist circumference and blood pressure were measured.The blood lipid, blood glucose and biochemical test were also tested. Venous blood was collected to detect serum insulin, omentin-1,leptin and adiponectin and analyze the correlation. Logistics regression analysis was used to evaluate the risk and protected factors of NAFLD. And ROC curve was used to assess diagnostic value of omentin-1, body mass index(BMI)and waist circumference for NAFLD. Results Serum omentin-1 level was significantly lower in obese children with NAFLD compared with other two groups(P<0.05). After adjusted for age and waist circumference, omentin-1 was negatively correlated with NAFLD,low-density lipoprotein level(LDL-C) and leptin/adiponectin (LAR), and was positively correlated with adiponectin (all P<0.05). Furthermore, Logistics regression analysis showed BMI, HOMA-IR were risk factors for NAFLD, and omentin-1 was a protected factor (P<0.05). BMI, waist circumference and omentin-1 were helpful for NAFLD diagnosis. Conclusion Serum omentin-1 is related to childhood body lipid especially central obesity,lipid disorder and NAFLD, which may be a beneficial adiposity factor helpful to improve childhood NAFLD.
Key words
omentin-1 /
non-alcoholic fatty liver disease /
adipokine /
children
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References
[1] 杨彦慧.儿童肥胖症的致病因素及干预策略探讨[J]. 数理医药学杂志, 2015,28(8):1248-1249.
[2] Jazet I, Pijl H, Meinders A. Adipose tissue as an endocrine organ: impact on insulinresistance[J]. Neth J Med, 2003, 61 (6): 194-212.
[3] Yang RZ, Xu M, Pray J, et al. Cloning of omentin, a new adipocytokine from omental fat tissue in humans[C]// Meeting of American Diabetes Association,New Orleans, Diabetes, 2003,52:1-A730.
[4] 张洁, 洪燕青, 邸阜生,等. 网膜素与2型糖尿病非酒精性脂肪肝病的病例对照研究[J]. 中国糖尿病杂志, 2012, 20 (11):833-835.
[5] 吴田英, 毛红芳. 儿童单纯性肥胖研究进展[J]. 上海预防医学, 2012, 23(11):577-579.
[6] 中华医学会肝脏病学分会脂肪肝和酒精性肝病学组. 非酒精性脂肪性肝病诊疗指南[J]. 中华内科杂志, 2010, 49(3):1-3.
[7] Brown SR, Lipshultz SE. Childhood metabolic syndrome and cancer risk[M]//Pediatric Metabolic Syndrome,2012:217-228.
[8] Weiss R, Dziura J, Burgert TS, et al. Obesity and the metabolic syndrome in children and adolescents[J]. N Engl J Med, 2004, 350 (23): 2362-2374.
[9] Rourke JL, Dranse HJ, Sinal CJ. Towards an integrative approach to understanding the role of chemerin in human health and disease[J]. Obes Rev, 2012,14 (3): 245-262.
[10] Yoo HJ, Hwang SY, Hong H C, et al. Association of circulating omentin-1 level with arterial stiffness and carotid plaque in type 2 diabetes[J]. Cardiovasc Diabetol, 2011, 10:103.
[11] Kazama K, Usui T, Okada M, et al. Omentin plays an anti-inflammatory role through inhibition of TNF-α-induced superoxide production in vascular smooth musclecells[J]. Eur J Pharmacol, 2012, 686(1-3):116-123.
[12] 周泽伟. 网膜素与非酒精性脂肪性肝病[J]. 现代医药卫生, 2012, 28(19):2956-2957.
[13] Inoue M, Maehata E, Yano M, et al. Correlation between the adiponectin-leptin ratio and parameters of insulin resistance in patients with type 2 diabetes[J]. Metabolism, 2005, 54 (3): 281-286.
[14] Kotani Y, Yokota I, Kitamura S, et al. Plasma adiponectin levels in newborns are higher than those in adults and positively correlated with birthweight[J]. Clin Endocrinol, 2004, 61 (4): 418-423.
[15] Pasarín M, Mura VL, Graciasancho J, et al. Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD[J]. Plos One, 2012, 7(4):e32785.
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