Meta-analysis of the effect of probiotics supplementation during pregnancy and early infancy on preventing children eczema

HUANG La-fang; HE Zhen; YIN Dao-gen; WANG Qing-chuan; LIAO Xiao-bing; DUAN Xue-yan

doi:10.11852/zgetbjzz2018-26-08-17

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (8) : 873-877. DOI: 10.11852/zgetbjzz2018-26-08-17

Meta-analysis of the effect of probiotics supplementation during pregnancy and early infancy on preventing children eczema

HUANG La-fang, HE Zhen,YIN Dao-gen,WANG Qing-chuan, LIAO Xiao-bing, DUAN Xue-yan

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Abstract

Objective To evaluate the effect of probiotics supplementation on preventing children eczema systematically. Methods Randomized controlled trial studies regarding the effect of probiotics supplementation during pregnancy and early infancy on preventing children eczema since 2000 were analyzed by Meta-analysis with Rev Man 5.3 software.The fixed effect model or random effect model was selected by the heterogeneity test results.The RR value and 95%CI were calculated,publication bias was evaluated, and sensitivity analysis was conducted.Subgroup analysis was conducted according to different strains and different end time of follow-up. Results Totally 23 published articles were selected, including 3 004 intervention cases and 3 016 control cases.The RR and 95%CI of probiotics supplementation preventing children eczema was 0.76(95%CI:0.65~0.89) (P＜0.05);Subgroup analysis revealed that the RR and 95%CI of probiotic mixtures was 0.56(95%CI:0.41~0.78)(P＜0.05);The end time of follow-up for≤12 months and ≤24 months were 0.69(95%CI:0.51~0.93) (P＜0.05) and 0.77(95%CI:0.60~0.98) (P＜0.05), respectively. Conclusions In order to prevent children atopic eczema, probiotics supplementation during pregnancy and early infancy should be promoted.Moreover, probiotic mixtures with Lactobacillus and Bifidobacterium are the best choice.

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probiotics / atopic eczema / randomized controlled trials / Meta-analysis

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HUANG La-fang, HE Zhen,YIN Dao-gen,WANG Qing-chuan, LIAO Xiao-bing, DUAN Xue-yan. Meta-analysis of the effect of probiotics supplementation during pregnancy and early infancy on preventing children eczema[J]. Chinese Journal of Child Health Care. 2018, 26(8): 873-877 https://doi.org/10.11852/zgetbjzz2018-26-08-17

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