Meta-analysis on the association between breastfeeding and childhood autism

YIN Dao-gen; HE Zhen; LI Min; DUAN Xue-yan; HUANG Jun-fang

doi:10.11852/zgetbjzz2018-26-07-16

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (7) : 754-757. DOI: 10.11852/zgetbjzz2018-26-07-16

Meta-analysis on the association between breastfeeding and childhood autism

YIN Dao-gen, HE Zhen, LI Min, DUAN Xue-yan, HUANG Jun-fang

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Abstract

Objective To analyze the association between breastfeeding and childhood autism,in order to provide theoretical basis for the prevention and treatment of autism. Methods Case-control studies on the association between breastfeeding and childhood autism from 2006 to 2017 were analyzed by Meta-analysis with Revman5.3 software.The fixed effect model or random effect model were selected by the heterogeneity test results.The OR value and 95%CI were calculated,publication bias and sensitivity analysis were conducted.Subgroup analysis was conducted according to the breastfeeding duration time (>1 m,>3 m,>6 m,>12 m). Results Totally 11 published articles (13 studies) were selected,including 2 323 cases and 2 839 control cases.The OR and 95%CI of breastfeeding associated with autism were [0.49(0.35~0.68)] (P＜0.05); Subgroup analysis revealed that the values of OR and 95%CI of breastfeeding duration >3 months and >6 months were [0.66(0.49~0.91)] and [0.40(0.32~0.49)](both P＜0.05),respectively. Conclusion Breastfeeding may be a protective factor for childhood autism.So breastfeeding at least for 6 months is suggested to be promoted.

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autism / breastfeeding / case-control study / meta-analysis.

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YIN Dao-gen, HE Zhen, LI Min, DUAN Xue-yan, HUANG Jun-fang. Meta-analysis on the association between breastfeeding and childhood autism[J]. Chinese Journal of Child Health Care. 2018, 26(7): 754-757 https://doi.org/10.11852/zgetbjzz2018-26-07-16

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