Study on the association between peri-pregnancy factors and childhood autism

LI Zhun; YANG Shao-ping; TANG Jun; YANG Sen-bei; PAN Shu-ya; JIANG Wei-wei; ZHANG Jing

doi:10.11852/zgetbjzz2018-26-07-06

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (7) : 717-720. DOI: 10.11852/zgetbjzz2018-26-07-06

Study on the association between peri-pregnancy factors and childhood autism

LI Zhun¹, YANG Shao-ping², TANG Jun³, YANG Sen-bei¹, PAN Shu-ya¹, JIANG Wei-wei⁴, ZHANG Jing¹

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Abstract

Objective To explore the peri-pregnancy risk factors for childhood autism,in order to provide evidence for prevention and intervention. Methods A 1∶3 matched case-control study was used in this research.A total of 180 autistic children in two medical institutions of Wuhan were selected as case group from 2013 to 2015,and 540 healthy children in Wuhan were recruited as control group.Caregivers or parents were investigated by using self-designed Childhood Psychological and Behavioral Development and Related Factors Questionnaire.Epidata 3.1 software was used for data-entry.Statistical analysis was conducted via SPSS 24.0 software. Results Factors that may increase risk for childhood autism included maternal stress during pregnancy (OR=20.118,95%CI: 9.812~60.696),postterm pregnancy (OR=7.379,95%CI: 1.328~40.985),pregnancy diseases (OR=2.876,95%CI: 1.528~5.414),pre-pregnancy overweight/obesity (OR=2.309,95%CI: 1.184~4.501),history of adverse pregnancy outcomes (OR=1.678,95%CI: 1.056~2.665),neonatal asphyxia (OR=4.624,95%CI: 1.416~15.105),paternal age≥30 (OR=2.712,95%CI: 1.711~4.299),paternal education of junior college/undergraduate/+(OR=6.511,95%CI: 3.878~10.931). Conclusion Several peri-pregnancy factors are associated with childhood autism,positive peri-pregnancy care may reduce these factors and subsequently decrease the risk of autism.

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childhood autism / peri-pregnancy / risk factors

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LI Zhun, YANG Shao-ping, TANG Jun, YANG Sen-bei, PAN Shu-ya, JIANG Wei-wei, ZHANG Jing. Study on the association between peri-pregnancy factors and childhood autism[J]. Chinese Journal of Child Health Care. 2018, 26(7): 717-720 https://doi.org/10.11852/zgetbjzz2018-26-07-06

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