Research on the association between Dubowitz neurological assessment and the outcome of developmental behavior in late-preterm infants

LIN Sen-ran; LI Yun; CUI Wei; GU Gui-xiong; HUA Jing

doi:10.11852/zgetbjzz2018-26-07-03

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (7) : 705-708. DOI: 10.11852/zgetbjzz2018-26-07-03

Research on the association between Dubowitz neurological assessment and the outcome of
developmental behavior in late-preterm infants

LIN Sen-ran^1,2, LI Yun^1,2, CUI Wei^1,2, GU Gui-xiong^1,2, HUA Jing¹

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Abstract

Objective To preliminarily examine the predictive validity of the Dubowitz Neurological Assessment-2nd Edition (The Neurological Assessment of the Preterm and Full-term Newborn Infant-second edition) to the outcome of developmental behavior in late-preterm infants,in order to provide basis for improving the follow-up system of late-preterm infants. Methods A total of 116 low-risk late-preterm (34⁺⁰~36⁺⁶ gestational weeks) infants born in Shanghai First Maternity and Infant Hospital from October 2016 to March 2017 were selected into the follow-up cohort.Dubowitz Neurological Assessment was performed at ultra-early stage (within 6 hours after birth) and at term age (40-week corrected gestational age) respectively.Bayley-Ⅲ (Bayley Scale of Infant Development-3rd Edition) was used to assess developmental outcome at corrected age 6 months .Pearson correlation coefficients were used to analyze the correlation between Dubowitz Neurological Assessment scores and Bayley-Ⅲ cognitive and motor composite scores. Results The cognitive composite scores of corrected age of 6 months were associated with abnormal signs of both ultra-early stage (r=0.184, P＜0.05) and term age (r=-0.187, P＜0.05),and were related to the scores of posture and tone and reflex(r=0.187,0.182,P＜0.05).The motor composite scores were related to posture and tone and abnormal signs (r=0.201,0.219,P＜0.05). Conclusion The Dubowitz Neurological Assessment has a certain predictive value for the outcome of developmental behavior of late-preterm infants, and further study is warranted for the application in a larger population.

Key words

Dubowitz neurological assessment / developmental behavior / correlation / late-preterm infants

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LIN Sen-ran, LI Yun, CUI Wei, GU Gui-xiong, HUA Jing. Research on the association between Dubowitz neurological assessment and the outcome of
developmental behavior in late-preterm infants[J]. Chinese Journal of Child Health Care. 2018, 26(7): 705-708 https://doi.org/10.11852/zgetbjzz2018-26-07-03

References

[1] Richards JL,Kramer MS,Deb-Rinker P,et al.Temporal trends in late preterm and early term birth rates in 6 high-income countries in North America and Europe and association with clinician-initiated obstetric interventions [J].JAMA,2016,316(4):410-419.
[2] Gupta P,Mital R,Kumar B,et al.Physical growth,morbidity profile and mortality among healthy late preterm neonates [J].Indian Pediatrics,2017,54(8):629-634.
[3] Rabie NZ,Bird TM,Magann EF,et al.ADHD and developmental speech/language disorders in late preterm,early term and term infants [J].Journal of Perinatology,2015,35(8):660-664.
[4] Schonhaut L,Armijo I,Perez M.Gestational age and developmental risk in moderately and late preterm and early term infants [J].Pediatrics,2015,135(4):e835-841.
[5] Walsh JM,Doyle LW,Anderson PJ,et al.Moderate and late preterm birth: effect on brain size and maturation at term-equivalent age [J].Radiology,2014,273(1):232-240.
[6] Lily MS Dubowitz VD,Eugenio mercuri the neurological assessment of the preterm and full-term newborn infant [M].2nd ed.Water Street,Lavenham,Suffolk: Mac Keith Press,1999.
[7] Spittle AJ,Walsh JM,Potter C,et al.Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm [J].Dev Med Child Neurol,2017,59(2):207-215.
[8] Yu YT,Hsieh WS,Hsu CH,et al.A psychometric study of the Bayley Scales of Infant and Toddler Development- 3rd Edition for term and preterm Taiwanese infants [J].Res Dev Disabil,2013,34(11):3875-3883.
[9] Torras-Mana M,Gomez-Morales A,Gonzalez-Gimeno I,et al.Assessment of cognition and language in the early diagnosis of autism spectrum disorder: usefulness of the Bayley Scales of infant and toddler development.Third edition[J]. JIDR,2016,60(5):502-511.
[10] 徐姗姗,黄红,张劲松,等.贝利婴幼儿发育量表-第三版评价上海市婴幼儿发育水平的应用初探 [J].中国儿童保健杂志,2011,19(1):30-32.
[11] Romeo DM,Bompard S,Cocca C,et al.Neonatal neurological examination during the first 6h after birth [J].Early Hum Dev,2017,108:41-44.
[12] Romeo DM,Ricci D,Van Haastert IC,et al.Neurologic assessment tool for screening preterm infants at term age [J].J Pediatr,2012,161(6):1166-1168.
[13] Setanen S,Lehtonen L,Parkkola R,et al.Prediction of neuromotor outcome in infants born preterm at 11 years of age using volumetric neonatal magnetic resonance imaging and neurological examinations [J].Dev Med Child Neurol,2016,58(7):721-727.
[14] Setanen S,Lahti K,Lehtonen L,et al.Neurological examination combined with brain MRI or cranial US improves prediction of neurological outcome in preterm infants [J].Early Hum Dev,2014,90(12):851-856.
[15] 周丛乐,汤泽中,侯新琳.新生儿神经病学 [M].北京: 人民卫生出版社,2012.
[16] Kelly CE,Cheong JL,Gabra Fam L,et al.Moderate and late preterm infants exhibit widespread brain white matter microstructure alterations at term-equivalent age relative to term-born controls [J].Brain Imaging Behav,2016,10(1):41-49.