Objective To investigate the level of serum insulin-like growth factor-1(IGF-1),insulin-like growth factor binding protein-3(IGFBP-3) and the influencing factors for these two growth factors in children with obstructive sleep apnea hypopnea syndrome(OSAHS). Method Totally 220 children aged 3 to 6 with OSAHS and 40 children without sleep breathing disorder as controls in Kunming Children′s Hospital were enrolled in this study from July 2012 to July 2015.Participants with OSAHS were divided into mild,moderate and severe OSAHS group according to the value of apnea hypopnea index (AHI) obtained from the polysomnography (PSG). The level of serum IGF-1,IGFBP-3,body mass index(BMI),height and weight of all children were measured and compared among groups by variance analysis. The influencing factors of serum IGF-1,IGFBP-3 were determined by multiple stepwise regression analysis. Results The level of serum IGF-1 in the severe group was lower than other three groups(sever group vs. control group vs. mild group vs. moderate group:121.86±36.47 vs. 149.44±31.44 vs. 147.63±26.83 vs. 142.11±34.50,all P<0.05).The value of height in the severe group was lower than that in control group(102.64±5.95 cm vs. 105.22±6.03 cm,both P＜0.05).No significant differences were found in the level of serum IGFBP-3,BMI and weight among groups(all P＞0.05).The influencing factors for the level of serum IGF-1,IGFBP-3 in OSAHS children were the age and the lowest oxygen saturation(LSaO2) . Conclusions The growth retardation of children with OSAHS may be related to the reduction of the level of serum IGF-1,while hypoxia is associated with the fluctuation of the serum level of IGF-1 in OSAHS children.
Key words
obstructive sleep apnea /
child /
insulin-like growth factor-1 /
insulin-like growth factor-binding protein-3
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