Objective To investigate the risk factors for isolated premature thelarche (IPT) and idiopathic central precocious puberty (ICPP) of girls in Tianjin. Methods A total of 110 cases of simple early breast development and 127 cases of girls with idiopathic central precocious puberty in the Affiliated Hospital of Logistic University of PAP Hospital were selected from February 2016 to May 2017,1∶2 pairs were matched according to age,and 220 normal girls and 254 normal controls were selected as controls,questionnaire survey was conducted among all subjects. Results Logistic regression analysis showed that pollution factory near the address,mother's menarche age ≤13 years old,frequency of use of plastic products,animal food or high protein diet and pigment food containing preservatives were risk factors for IPT (OR=9.061,22.220,2.980,6.508 and 14.069,P＜0.05);Taking nutrition supplements,using adult wash skin care products,food containing hormones,mother's menarche age ≤13 years old and seafood diet were risk factors for ICPP (OR=3.071,2.445,4.063,2.809 and 2.849,P＜0.05). Conclusion The risk factors of IPT and ICPP in girls in Tianjin city are complex,which are related to maternal age at menarche,diet habits and so on.
Key words
isolated premature thelarche /
idiopathic central precocious puberty /
risk factors /
girls
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References
[1] 中华医学会儿科学分会内分泌遗传代谢学组,《中华儿科杂志》编辑委员会.中枢性性早熟诊断与治疗共识(2015)[J].中华儿科杂志,2015,53(6):412-418.
[2] 王蓬伟,周雅芮,苏永红,等.0～4岁女童单纯乳房早发育相关危险因素分析[J].中国医学工程,2015,23(9):71,73.
[3] 中华人民共和国卫生部.性早熟诊疗指南(试行)[J].中国儿童保健杂志,2011,19(4):390-392.
[4] 杨玉,王荻兰.207例0～2岁女童单纯乳房早发育相关危险因素分析[J].中国儿童保健杂志,2014,22(2):190-193.
[5] 顾威,沈卫星.玉米赤霉烯酮污染与儿童性早熟发病相关性研究进展[J].中华实用儿科临床杂志,2014,29(8):637-639.
[6] 谢蓉蓉,陈临琪,吴海瑛,等.特发性中枢性性早熟与单纯性乳房早发育的鉴别诊断[J].山东医药,2014,5(19):60-61.
[7] Krstevska KM,Jovanovska J,Tasic VB,et al.Mutational analysis of KISS1 and KISS1R in idiopathic central precocious puberty[J].JPEM,2014,27(1/2):199-201.
[8] 金献江,罗越,吴慧平,等.促性腺激素释放激素类似物治疗不同年龄中枢性性早熟女孩的剩余生长能力评价[J].中国全科医学,2014,10(25):2965-2968.
[9] 王春林,梁黎,留佩宁,等.促性腺激素释放激素类似物联合重组人生长激素对中枢性性早熟女童身高的影响[J].中国当代儿科杂志,2014,16(1):25-30.
[10] 任翼,谭志团,陆桂香,等.海口市6～8岁女童乳房发育现况调查[J].广东医学,2014,35(2):272-273.
[11] Rousseau NI,Kaduri S,Garfield N,et al.Hypothalamic hamartoma associated with central precocious puberty and growth hormone deficiency[J].JPEM,2014,27(1/2):117-121.
[12] 李豫川,巩纯秀,吴迪,等.以女童同性性早熟起病的青春期多囊卵巢综合征诊疗分析[J].中华实用儿科临床杂志,2014,29(8):595-598.
[13] 杨章萍,郑晓萍,张旭慧,等.女童性早熟的影响因素分析[J].中国学校卫生,2014,35(1):133-135.
[14] 陈瑞敏,蔡春艳,胡志坚,等.福建地区女童特发性中枢性性早熟危险因素分析[J].中华实用儿科临床杂志,2014,29(20):1543-1547.
[15] 邓英华,冯承芸,牛丽,等.宝安区4～10岁儿童性早熟现状调查及相关因素分析[J].中国妇幼保健,2014,29(11):1723-1725.
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