Objective To explore the characteristics and differences on speech-evoked auditory brainstem responses (speech-ABR) between children with autism spectrum disorder (ASD) and healthy children,and to investigate the relationship between speech-ABR and language development level. Methods Totally 18 healthy children and 15 children with ASD were enrolled in this study.The children's ability assessment was performed by specialists by using the Childhood Autism Rating Scale (CARS),the Autism Diagnostic Observation Schedule (ADOS),and the Gesell Development Diagnosis Scale (GDDS).All participants were tested by speech-ABR examinations.The latency,duration and amplitude of each wave were recorded. Results All waves latency of transient responses of speech-ABR in ASD children were delayed.Latency of sustained responses of E wave and F wave were significantly delayed.The language scores in GDDS were negatively correlated with the wave V,wave A and wave F latency in ASD(r=-0.525,-0.563,-0.580,P=0.04,0.029,0.024). Conclusion Brainstem deficits in ASD are manifested in the reduction of nerve synchronization.Brainstem and cortical encoding of speech sounds dysfunction may contribute to the language and social communication impairment in ASD.
Key words
autism spectrum disorder /
children /
speech-evoked auditory brainstem responses /
language proficiency
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References
[1] American Psychiatric Association.Diagnostic and Statistical Manual of Mental Disorders[M].5th Edition.Washington DC:American Psychiatric Publishing,2013.
[2] 符秋养.言语声诱发听性脑干反应电生理特性及其在言语识别功能评估中应用的研究[D].广州:南方医科大学,2015.
[3] Schopler E,Reichler RJ,Devellis RF,et al.Toward objective classification of childhood autism:Childhood Autism Rating Scale (CARS)[J].J Autism Dev Disord,1980,10(1):91-103.
[4] Lord C,Rutter M,Goode S,et al.Autism diagnostic observation schedule:a standardized observation of communicative and social behavior[J].J Autism Dev Disord,1989,19(2):185.
[5] Russo N,Nicol T,Trommer B,et al.Brainstem transcription of speech is disrupted in children with autism spectrum disorders[J].Developmental Science,2009,12(4):557.
[6] 李晓婷.学龄前期自闭症谱系障碍患儿与正常儿童言语诱发听性脑干反应的比较[D].北京:首都医科大学,2013.
[7] Johnson KL,Nicol TG,Kraus N.Brain stem response to speech:a biological marker of auditory processing[J].Ear & Hearing,2005,26(5):424-34.
[8] Jou RJ,Frazier TW,Keshavan MS,et al.A two-year longitudinal pilot MRI study of the brainstem in autism[J].Behav Brain Res,2013,251:163.
[9] Kraus N,Anderson S,White-Schwoch T,et al.The frequency-following response[M].Springer International Publishing,2017.
[10] 刘海峰,符秋养,苏园园,等.言语诱发听性脑干反应的稳定性研究[J].中国医学物理学杂志,2010,30(1):1635-1637,1644.
[11] 王硕.频率跟随反应在听觉脑干编码音调信息的临床应用性研究[J].中国耳鼻咽喉头颈外科,2016,23(1):12-14.
[12] Song JH,Banai K,Kraus N.Brainstem timing deficits in children with learning impairment may result from corticofugal origins[J].Audiol Neurotol,2008,13(5):335-344.
[13] Sanfins MD,Borges LR,Ubiali T,et al.Speech auditory brainstem response (speech ABR) in the differential diagnosis of scholastic difficulties[J].Braz J Otorhinolaryngol,2015,83(1):31-40.
[14] Malayeri S,Lotfi Y,Moossavi SA,et al.Brainstem response to speech and non-speech stimuli in children with learning problems[J].Hear Res,2014,313(4):75-82.
[15] 王建军,李乐加,刘芳.孤独症患者脑干听觉通路功能的评估与研究[J].癫痫与神经电生理学杂志,2012,21(5):288-290.
[16] 崔梓天.孤独症患儿中言语诱发的脑干听性反应研究[D].广州:华南师范大学,2017.
[17] Russo NM,Hornickel J,Nicol T,et al.Biological changes in auditory function following training in children with autism spectrum disorders[J].Behav Brain Funct,2010,6(1):60.
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