Meta-analysis on association of vitamin D intake in pregnancy with infants asthma

CHEN Hui; LIN Xiao-xia; CHEN Yan-hui

doi:10.11852/zgetbjzz2018-26-03-16

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (3) : 286-289. DOI: 10.11852/zgetbjzz2018-26-03-16

Meta-analysis on association of vitamin D intake in pregnancy with infants asthma

CHEN Hui, LIN Xiao-xia, CHEN Yan-hui

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Abstract

Objective To evaluate the association of vitamin D intake in pregnancy with infants asthma. Method VIP,Wanfang,CNKI,PubMed,and OVID databases were searched,in order to collect studies regarding association of vitamin D intake in pregnancy with infants asthma to conduct Meta-analysis. Results Totally 5 prospective cohort studies and 4 RCTs were included in this study.1)All 5 articles had reported that higher maternal intake of vitamin D during pregnancy may significantly decrease the risk of asthma or wheeze in early childhood.2)Two of the fore RCTs were conducted Meta-analysis finally.A total of 1 355 mother-children pairs were enrolled,including 683 pairs in group with vitamin D supplementation and 672 pairs in group with placebo.The Results showed that prenatal vitamin D supplementation was reduced the risk of infants asthma compared to the placebo (OR=0.71;95%CI:0.54～0.92;P=0.01). Conclusion Higher prenatal intake of vitamin D may decrease the risk of infants asthma.

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vitamin D / pregnancy / infants asthma / Meta-analysis

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CHEN Hui, LIN Xiao-xia, CHEN Yan-hui. Meta-analysis on association of vitamin D intake in pregnancy with infants asthma[J]. Chinese Journal of Child Health Care. 2018, 26(3): 286-289 https://doi.org/10.11852/zgetbjzz2018-26-03-16

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