Objective To investigate the main risk factors and pathogen distribution of preterm infants with nosocomial bacterial sepsis. Methods Totally 87 preterm infants with nosocomial bacterial septicemia from the Neonatology Department of the Maternal and Child Health Hospital Affiliated to Nanjing Medical University were recruited from May,2008 to April,2017.High risk factors and pathogens of sepsis were analyzed. Results The prevalence of preterm infants with nosocomial bacterial sepsis was 1.20%(87/7 221).The major pathogens of the infections among these premature infants included gram-positive bacteria(70.8%),especially staphylococcus epidermidis(33.3%),and gram-negative bacteria (29.2%),especially Klebsiella pneumoniae (42.3%).Logistic regression analysis showed that the very low birth weight(OR=1.9,95%CI:0.9~5.3,P=0.013),indwelling peripherlly inserted central catheter (PICC)(OR=3.3,95%CI:2.5~8.3,P=0.006),tracheal intubation (OR=2.3,95%CI:1.7~5.7,P=0.001) and twins (OR=1.5,95%CI:0.7~4.2,P=0.009) were high risk factors of preterm infants with nosocomial bacterial sepsis. Conclusion The very low birth weight,indwelling PICC,tracheal intubation and twins are high risk factors of neonates with nosocomial bacterial sepsis,whereas the leading pathogen is staphylococcus epidermidis.
Key words
preterm infants /
nosocomial infection /
septicemia /
risk factor
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