Objective To research the diagnostic value of serum neuron specific enolase (NSE) and catecholamine (CA) levels to severe hand foot mouth disease (HFMD) in children,and to provide reference for clinical evaluation of HFMD severity. Methods Totally 110 HFMD childen hospitalized in the Maternal and Child Health Care Hospital of Hainan Province from January 2014 to December 2015 were enrolled in this study.According to the Guide for the Diagnosis and Treatment of HFMD established in 2010 by the ministry of health,110 HFMD children were divided into mild group (44 cases),severe severe group (44 cases) and critical severe group (22 cases).The levels of NSE and CA were tested and compared among three groups.And the relationship between the levels of NSE,CA and the severity of HFMD was analyzed. Results 1)The levels of NSE and epinephrine(E),dopaminel (NE) in severe group were significantly higher than those in the mild group (Pˉ0.05).2) The levels of NSE and E,NE,DA in critical severe group were significantly higher than those in the severe severe group (Pˉ0.05).3)The levels of NSE,E,NE,DA levels were positively related to the severity of HFMD (r=0.366,0.590,0.425,0.345,all P<0.05). Conclusion The levels of NSE and NE would increase with the disease progressing.And the levels of NSE and NE can be used as a reference indicator to assess the severity of HFMD.
Key words
hand foot and mouth disease /
severe /
neuron specific enolase /
catecholamine /
children
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