Risk factors and prognosis of obesity in breast-fed infants

TENG Xiao-yu, YANG Zhao-chuan, YI Ming-ji

Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (2) : 171-173.

PDF(410 KB)
PDF(410 KB)
Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (2) : 171-173. DOI: 10.11852/zgetbjzz2018-26-02-15

Risk factors and prognosis of obesity in breast-fed infants

  • TENG Xiao-yu, YANG Zhao-chuan, YI Ming-ji
Author information +
History +

Abstract

Breast feeding is considered to offer optimal nutrition for healthy growth and development of infants.In recent years,the observational studies have shown breast feeding may prevent the occurrence of childhood obesity.However,some breast-fed infants especially exclusively breast-fed have excessive weight gain.The influences contributing to high weight gain and effects on the long-term health development are followed.This article summarizes the risk factors and prognosis of excessive weight gain in breast-fed infants.It shows the high level of protein content,the high levels of insulin-like growth factor-1(IGF-1),ghrelin,leptin,and oligosaccharide diversity in breast milk may be the risk factors for obesity in breast-fed children.Feeding behaviors,such as feeding breast milk by bottle,more feeding times at night,long duration and short interval in feeding,might be related to obesity in breast-fed children.Researches have shown overweight or obesity in infancy would increase the risk of childhood obesity whether they are breastfed or formula fed.

Key words

breastfeeding / obesity / risk factor / prognostic analysis

Cite this article

Download Citations
TENG Xiao-yu, YANG Zhao-chuan, YI Ming-ji. Risk factors and prognosis of obesity in breast-fed infants[J]. Chinese Journal of Child Health Care. 2018, 26(2): 171-173 https://doi.org/10.11852/zgetbjzz2018-26-02-15

References

[1] Grunewald M,Hellmuth C,Demmelmair H,et al.Excessive weight gain during full breast-feeding[J].Ann Nutr Metab,2014,64(3-4):271-275.
[2] Perrella SL,Geddes DT.A case report of a breastfed infant's excessive weight gains over 14 months[J].J Hum Lact,2016,32(2):364-368.
[3] Kon IY,Shilina NM,Gmoshinskaya MV,et al.The study of breast milk IGF-1,leptin,ghrelin and adiponectin levels as possible reasons of high weight gain in breast-fed infants[J].Ann Nutr Metab,2014,65:317-323.
[4] ÇatlI G,Olgağ Dündar N,Dündar BN.Adipokines in breast milk:an update[J].J Clin Res Pediatr Endocrinol,2014,6(4):192-201.
[5] Khodabakhshi A,Ghayour-Mobarhan M,Rooki H,et al.Comparative measurement of ghrelin,leptin,adiponectin,EGF and IGF-1 in breast milk of mothers with overweight/obese and normal-weight infants[J].Eur J Clin Nutr,2015,69(5):614-618.
[6] Hahn-Holbrook J,Le TB,Chung A,et al.Cortisol in human milk predicts child BMI[J].Obesity (Silver Spring,Md.),2016,24(12):2471-2474.
[7] Lemas DJ,Young BE,Baker PR,et al.Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome[J].Am J Clin Nutr.2016,103(5):1291-1300.
[8] Alderete TL,Autran C,Brekke BE,et al.Associations between human milk oligosaccharides and infant body composition in the first 6 mo of life[J].Am J Clin Nutr,2015,102(6):1381-1388.
[9] De Luca A,Hankard R,Alexandre-Gouabau MC,et al.Higher concentrations of branched-chain amino acids in breast milk of obese mothers[J].Nutrition,2016,32(11-12):1295-1298.
[10] Rudolph MC,Young BE,Lemas DJ,et al.Early infant adipose deposition is positively associated with the n-6 to n-3 fatty acid ratio in human milk independent of maternal BMI[J].Int J Obes (Lond),2016,13:1-8.
[11] Walshaw CA,Owens JM,Scally AJ,et al.Does breastfeeding method influence infant weight gain?[J].Arch Dis Child,2008,93(4):292-296.
[12] 李音,衣明纪,胡晓燕,等.完全母乳喂养婴儿超重的危险因素分析[J].实用儿科临床杂志,2012,27(5):366-368.
[13] Li R,Magadia J,Fein SB,et al.Risk of bottle-feeding for rapid weight gain during the first year of life[J].Arch Pediatr Adolesc Med,2012,166(5):431-436.
[14] Li R,Scanlon KS,May A,et al.Bottle-feeding practices during early infancy and eating behaviors at 6 years of age[J].Pediatrics,2014,134(Suppl 1):70-77.
[15] Brown A,Raynor P,Lee.Maternal control of child-feeding during breast and formula feeding in the first 6 months post-partum[J].J Hum Nutr Diet,2011,24(2):177-186.
[16] Li R,Fein SB,Grummer-Strawn LM.Do infants fed from bottles lack self-regulation of milk intake compared with directly breastfed infants?[J].Pediatrics,2010,125(6):e1386-e1393.
[17] Yuan WL,Lange C,Schwartz C,et al.Infant dietary exposures to sweetness and fattiness increase during the first year of life and are associated with feeding practices[J].Nutr,2016,146(11):2334-2342.
[18] Cheng TS,Loy SL,Toh JY,et al.Predominantly night time feeding and weight outcomes in infants[J].Am J Clin Nutr,2016,104(2):380-388.
[19] Bailey LC,Forrest CB,Zhang P,et al.Association of antibiotics in infancy with early childhood obesity[J].JAMA Pediatr,2014,168(11):1063-1069.
[20] Saari A,Virta LJ,Sankilampi U,et al.Antibiotic exposure in infancy and risk of being overweight in the first 24 months of life[J].Pediatrics,2015,135:617-626.
[21] Lemas DJ,Yee S,Cacho N,et al.Exploring the contribution of maternal antibiotics and breastfeeding to development of the infant microbiome and pediatric obesity[J].Semin Fetal Neonatal Med,2016,21(6):406-409.
[22] Korpela K,Salonen A,Virta LJ,et al.Association of early-life antibiotic use and protective effects of breastfeeding:role of the intestinal microbiota[J].JAMA Pediatrics,2016,170(8):750-757.
[23] van der Willik EM,Vrijkotte TG,Altenburg TM,et al.Exclusively breastfed overweight infants are at the same risk of childhood overweight as formula fed overweight infants[J].Arch Dis Child,2015,100(10):932-937.
[24] Oddy WH.Being overweight in infancy predicts overweight in childhood regardless of infant feeding method[J].Evidbased Nurs,2016,19(2):50.
[25] 季成叶.从胎儿到青春期-肥胖发生和流行的生长发育轨迹[J].中国儿童保健杂志,2010,18(06):445-447.
[26] 戎芬.出生体重与环境因素对儿童青少年超重肥胖影响的队列研究[D].上海:复旦大学,2012.
[27] Dietz WH.The obesity epidemic in young children.Reduce television viewing and promote playing[J].BMJ,2001,322(7282):313-314.
[28] Yakubov R,Nadir E,Stein R,et al.The duration of breastfeeding and its association with metabolic syndrome among obese children[J].Scientific World Journal,2015,2015:731319.
PDF(410 KB)

Accesses

Citation

Detail

Sections
Recommended

/