Objective To investigate serum levels of 25-hydroxyvitamin D[25(OH)D] and its correlation with pulmonary functions and IgE,and to analyse the relationship between 25(OH)D and asthma. Methods A total of fifty asthma children treated in pediatrics of Weifang Maternity and Children Healthcare Hospital from 2015 to 2016 were chosen as asthmatic group,while 50 healthy children were selected as control group.Serum 25(OH)D and IgE were tested by ELISA.And pulmonary function indicators,including forced vital capacity (FVC),forced expiratory volume in 1 second (FEV1) and FEV1/FVC% were measured by a device testing pulmonary function.Serum levels of 25(OH)D between asthmatic group and control group were compared,while its correlation with severity of asthma was calculated. Results The level of serum 25(OH)D was significantly lower in children with asthma(19.54±7.85)than that in control group(25.28±3.48)(t=5.679,P＜0.05).Positive correlation existed between vitamin D levels and FVC,FEV1and FEV1/FVC% (r=0.375,0.339,0.384).A negative relationship existed between vitamin D levels and IgE serum levels (r=-0.534). Conclusions Vitamin D deficiency is prevalent in children with asthma.There is a strong correlation between 25(OH)D and asthma severity.
Key words
vitamin D /
asthma in children /
pulmonary functions /
serum IgE
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] 吴怡玲,邵洁.哮喘儿童血清25羟维生素D及其免疫相关因素分析[J].中国实用儿科杂志,2013,12(28):917-920.
[2] Riverin BD,Maguire JL,Li P.Vitamin D supplementation for childhood asthma: A systematic review and meta-analysis[J].PLoS One,2015,10(8):e0136841.
[3] 中华医学会儿科学分会呼吸学组.中华儿科杂志编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745-750.
[4] 全国佝偻病防治科研协作组.中国优生科学协会小儿营养专业委员会.维生素D缺乏及维生素D缺乏性佝偻病防治建议[J].中国儿童保健杂志,2015,23(7):781-782.
[5] 中华医学会儿科学分会儿童保健学组.《中华儿科杂志》编辑委员会.儿童微量营养素缺乏防治建议[J].中华儿科杂志,2010,48(7):502-509.
[6] Ayulo M,Katyal C,Agarwal Ch,et al.The prevalence of vitamin D deficiency and its relationship with disease severity in an urban pediatric critical care unit[J].Endocr Regul,2014,48(2):69-76.
[7] Zahedirad M,Nikooyeh B,Hall SC,et al.The epidemic of poor vitamin D status among 9-12 years old children in Tehran,2008,using HPLC: need for an urgent action[J].Nutr Food Sci Res,2015,2:15-20.
[8] Barker T,Martins TB,Hill HR,et al.Vitamin D sufficiency associates with an increase in anti-inflammatory cytokines after intense exercise in humans[J].Cytokine,2014,65(2):134-137.
[9] Samaha HMS,Elsaid AR,et al.Vitamin D and markers of airway inflammation in asthma[J].Egypt J Chest Dis Tuberc,2015,64:779-783.
[10] Fares MM,Alkhaled LH,Mroueh SM,et al.Vitamin D supplementation in children with asthma: a systematic review and meta-analysis[J].BMC Res Notes,2015,3(8):23.
[11] Agrawal T,Gupta GK,Agrawal DK,et al.Vitamin D supplementation reduces airwayhyper-esponsiveness and allergic airway inflammation in a murine model[J].Clin Exp Allergy,2013,43(6):672-683.
[12] 尹加林,杨乐,蒲海波,等.哮喘患儿血清1,25－二羟维生素D3和IL－25与肺功能及生活质量的相关性研究[J].中国妇幼保健,2016,36(1):106-108.
[13] Uysalol M,Mutlu LC,Saracoglu GV,et al.Childhood asthma and vitamin D deficiency in Turkey:is there cause and effect relationship between them[J].Ital J Pediatr,2013,39:78.
[14] Bar Yoseph R,Livnat G,Schnapp Z,et al.The effect of vitamin D on airway reactivity and inflammation in asthmatic children: a double-blind placebo-controlled trial[J].Pediatr Pulmonol,2015,50(8):747-753.
[15] 李晓娅,王小妮,陆小霞.维生素D与儿童哮喘相关性的Meta分析[J].中国儿童保健杂志,2016,24(12):1290-1295.
PDF(468 KB)
