Objective To systematically review the current status of genomics research in patients with tic disorder (TDs) in China,and to summarize the genes related to disease susceptibility and the effects of drug treatment,so as to provide evidence for the prevention and treatment of TDs. Methods Pubmend,Embase,Cochrane library,CBM,CNKI,VIP,and Wanfang databases were searched from inception to July 2017.Studies which assessed the association between related genes and TDs were included and then descriptive analysis were used to summarize the result. Results A total of 43 studies involving 3 723 children and 2 433 families were included.The age of participants ranged from 3 to 22 years old.Publication time was between 2001 and 2016.Only 44.2% (19/43) included studies reported a positive Conclusion.Included studies involved 24 genes,only 4 positive genes were associated with TDs disease,1 positive gene was related to drug efficacy,5 positive genes were related to TDs with comorbidity. Conclusions The researches of genome in TDs develop rapidly,and the related genes are diverse and complicated.However,the sample size is small,and less positive genes are found,also there is a lack of the standard method and path for the clinical transformation from gene research to clinical practice.Most studies need to be validated by high-quality and large sample clinical studies in order to provide evidence to guide clinical practice.
Key words
tic disorders /
Tourette syndrome /
gene polymorphism /
evidence-based assessment
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