Role of regulatory T-cells in different clinical expressions of Helicobacter pylori infection

WANG Fang-fang; XIE Qing-zhi

doi:10.11852/zgetbjzz2018-26-01-13

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (1) : 48-50. DOI: 10.11852/zgetbjzz2018-26-01-13

Role of regulatory T-cells in different clinical expressions of Helicobacter pylori infection

WANG Fang-fang, XIE Qing-zhi

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Abstract

Helicobacter pylori (H.pylori) colonization can induce vigorously innate and specific immune responses.However,the infection will not disappear and chronic active gastritis will continue if left untreated.It has been established that the topographical pattern of gastritis and its immune response are the main causes for the persistence of bacteria and the clinical outcome.There have been many controversies over the role of Treg cells in H.pylori infection.Treg cells can inhibit the body's immune response to Hp,thereby reducing the incidence of acute inflammation.At the same time,the response inhibition also causes long-term colonization of Hp in gastric mucosa and the persistence of chronic infection,leading to the further development of the disease.This paper reviews the role of Treg in different clinical expressions of H.Pylori infection.

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Helicobacter pylor / regulatory T-cell / children / gastric cancer

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WANG Fang-fang, XIE Qing-zhi. Role of regulatory T-cells in different clinical expressions of Helicobacter pylori infection[J]. Chinese Journal of Child Health Care. 2018, 26(1): 48-50 https://doi.org/10.11852/zgetbjzz2018-26-01-13

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