Research advances on zinc finger protein ZBTB38 regulating growth and development

ZHAO Qian-qian; BAN Bo; SHAO Qian

doi:10.11852/zgetbjzz2018-26-01-12

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Chinese Journal of Child Health Care ›› 2018, Vol. 26 ›› Issue (1) : 44-47. DOI: 10.11852/zgetbjzz2018-26-01-12

Research advances on zinc finger protein ZBTB38 regulating growth and development

ZHAO Qian-qian¹, BAN Bo², SHAO Qian³

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Abstract

Zinc finger protein ZBTB38 is a new member of the ZBTB zinc finger protein subfamily,homologous to known BCL6 and PLZF.Through the study,scholars have found that ZBTB38 plays an important role in growth and development,tumorigenesis,cytoskeletal tissue,stem cell homeostasis and transcription regulation,hematopoiesis,chromatin remodeling and protein degradation.Abnormal expression or dysfunction of ZBTB38 can lead to individual developmental disorders and is closely related to the pathophysiological process of tumor,prion disease and other major diseases.With the rapid development of technology,especially single nucleotide polymorphism,genomic hybridization,genome sequencing research,ZBTB38 gene was found to have strong correlation with human height.Zinc finger protein ZBTB38 regulating growth and development is reviewed in this paper.

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zinc finger protein / ZBTB38 / growth and development

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ZHAO Qian-qian, BAN Bo, SHAO Qian. Research advances on zinc finger protein ZBTB38 regulating growth and development[J]. Chinese Journal of Child Health Care. 2018, 26(1): 44-47 https://doi.org/10.11852/zgetbjzz2018-26-01-12

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