Research advances on the role of vitamin D in attention deficit/hyperactivity disorder children

LI Man-man; YANG Shu-fen

doi:10.11852/zgetbjzz2018-1792

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (9) : 979-981. DOI: 10.11852/zgetbjzz2018-1792

Research advances on the role of vitamin D in attention deficit/hyperactivity disorder children

LI Man-man, YANG Shu-fen

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Abstract

As a neurosteroid,vitamin D plays an important role in brain proliferation,differentiation,neurotrophic,neurotransmitters and neuroplasticity.Recently,studies have shown that the level of vitamin D in ADHD children is lower than that in healthy children,which may be related to the pathogenesis of ADHD.So this article reviews the mechanism of action of vitamin D in the development of ADHD in children.

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vitamin D / attention deficit/hyperactivity disorder in children / neurodevelopment

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LI Man-man, YANG Shu-fen. Research advances on the role of vitamin D in attention deficit/hyperactivity disorder children[J]. Chinese Journal of Child Health Care. 2019, 27(9): 979-981 https://doi.org/10.11852/zgetbjzz2018-1792

References

[1] Feldman HM,Reiff MI.Attention deficit-hyperactivity disord er in children and adolescents[J].NEJM,2014,370(9):838-846.
[2] Gallo EF,Posner J.Moving towards causality in attention-deficit hyperactivity disorder:overview of neural and genetic mechanisms[J].Lancet Psychiatry,2016,3(6):555-567.
[3] Morales E,Julvez J,Torrent M,et al.Vitamin D in pregnancy and attention deficit hyperactivity disorder-like symptoms in childhood[J].Epidemiology,2015,26(4):458-465.
[4] MáováL,Biíková M,Ostatníková D,et al.Vitamin D,neuros teroids and autism.[J].Physiol Res,2017,66(Suppl 3):333-340.
[5] Hawes JE,Tesic D,Whitehouse AJ,et al.Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse[J].Behav Brain Res,2015,286:192-200.
[6] Cannell JJ.Vitamin D and autism,what′s new?[J].Rev Endocr Metab Disord,2017,18(2):183-193.
[7] Biswas S,Kanwal B,Jeet C,et al.Fok-I,Bsm-I,and Taq-I variants of vitamin D receptor polymorphism in the development of autism spectrum disorder:a literature review[J].Cureus,2018,10(8):e3228.
[8] Matthews M,Nigg JT,Fair DA.Attention deficit hyperactivity disorder[J].Curr Top Behav Neurosci,2014,16(2):235.
[9] Gajria K,Lu M,Sikirica V,et al.Adherence,persistence,and medication discontinuation in patients with attention-deficit/hyperactivity disorder - asystematic literature review[J].Neuropsych Dis Treat,2014,10:1543-1569.
[10] Evangelia K,Elisavet K,Despina NP.Vitamin D levels in children and adolescents with attention-deficit hyperactivity disorder (ADHD):a meta-analysis[J].Atten Defic Hyperact Disord,2018.doi:10.1007/s12402-018-0276-7.
[11] Khoshbakht Y,Bidaki R,Salehi-Abargouei A.Vitamin D status and attention deficit hyperactivity disorder:a systematic review and meta-analysis of observational studies[J].Adv Nutr,2018,9(1):9-20.
[12] Sahin N,Altun H,Kurutas EB,et al.Vitamin D and vitamin D receptor levels in children with attention-deficit/hyperactivity disorder[J].Neuropsychiatr Dis Treat,2018,14:581-585.
[13] Mossin MH,Aaby JB,Dalgard C,et al.Inverse associations between cord vitamin D and attention deficit hyperactivity disorder symptoms:a child cohort study[J].Aust NZ J Psychiat,2017,51(7):703-710.
[14] Elshorbagy HH,Barseem NF,Abdelghani WE,et al.The impact of vitamin D supplementation on attention-deficit hyperactivity disorder in children[J].Ann Pharmacother,2018.doi:10.10071s12519-018-0209-8.
[15] Dehbokri N,Noorazar G,Ghaffari A,et al.Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder[J].World J Pediatr,2018.doi:10.1007/2519-018- 0209-8.
[16] Chawla D,Fuemmeler BF,Benjaminneelon SE,et al.Early prenatal vitamin D concentrations and social-emotional development in infants[J].J Maternal-fetal Neo M,2017,1:1-251.
[17] Lange KW.Dietary factors in the etiology and therapy of attention deficit/hyperactivity disorder[J].Curr Opin Clin Nutr Metab Care,2017,20(6):464-469.
[18] Saedisomeolia A,Samadi M,Gholami F,et al.Vitamin D′s molecular action mechanism in attention-deficit/hyperactivity disorder:a review of evidence[J].CNS Neurol Disord Drug Targets,2018,17(4):280-290.
[19] Berridge MJ.Vitamin D cell signalling in health and disease[J].Biochem Bioph Res Co,2015,460(1):53-71.
[20] Deluca HF.Vitamin D:historical overview[J].Vitam Ho rm,2016,100:1-20.
[21] Cui X,Pertile R,Liu P,et al.Vitamin D regulates tyrosine hydroxylase expression:N-cadherin a possible mediator[J].Neuroscience,2015,304:90-100.
[22] Patrick RP,Ames BN.Vitamin D hormone regulates serotonin synthesis.Part 1:relevance for autism[J].Faseb J,2014,28(6):2398-2413.
[23] Tang H,Hua F,Wang J,et al.Progesterone and vitamin D combination therapy modulates inflammatory response after traumatic brain injury[J].Brain Injury,2015,29(10):1-10.
[24] Cantorna MT,Waddell A.The vitamin D receptor turns off chronically activated T cells[J].Ann N Y Acad Sci,2014,1317:70-75.
[25] Patrick RP,Ames BN.Vitamin D and the omega-3 fatty acids control serotonin synthesis and action,part 2:relevance for ADHD,bipolar disorder,schizophrenia,and impulsive behavior[J].Faseb J,2015,29(6):2207-2222.
[26] Banerjee E,Nandagopal K.Does serotonin deficit mediate susceptibilityto ADHD[J].Neurochem Int,2015,82:52-68.
[27] Lai TKY,Su P,Zhang H,et al.Development of a peptide targeting dopamine transporter to improve ADHD-like deficits[J].Mol Brain,2018,11(1):66.
[28] Cui X,Gooch HM,Groves NJ,et al.Vitamin D and the brain:key questions for future research[J].J Steroid Biochem,2015,148:305-309.
[29] Pertile RAN,Cui X,Eyles DW.Vitamin D signaling and the differentiation of developing dopamine systems[J].Neuroscience,2016,333:193-203.
[30] Berridge MJ.Vitamin D deficiency:infertility and neurodevelopmental diseases (attention deficit hyperactivity disorder,autism,and schizophrenia)[J].Am J Physiol Cell Physiol,2018,314(2):C135-C151.