Objective To explore the correlation between growth rate of small for gestational age(SGA) infants and the risk of obesity in school-age children by longitudinal cohort study,so as to provide theoretical basis for making corresponding prevention and control measures. Methods A cohort study including 2 079 SGA infants was conducted from 2004 to 2011,who were followed up to 6 years old from birth.Height,weight and head circumference of SGA infants were measured,and their physical conditions were assessed by the World Health Organization (WHO) standards. Results According to Z score (ΔWAZ) of body weight change in the first four months after birth,the participants were divided into 4 groups,including slow growth rate (ΔWAZ<-0.67),moderate growth rate (ΔWAZ-0.67-0.67),rapid growth rate (ΔWAZ 0.67-1.28),and extremely rapid growth rate (ΔWAZ＞1.28).The overweight and obesity risks increased with the increasing of growth rate.Compared with children with moderate growth rate,the risk of overweight and obesity in rapid growth rate and extremely rapid growth rate groups were 11.91 times and 2.34 times higher than those in the moderate growth rate group,respectively(OR=11.91,95%CI:9.04-15.76,P<0.001;OR=2.34,95%CI:1.80-3.03,P<0.001).And the risk for emaciation significantly increased in slow growth rate group(OR=2.48,95%CI:1.81-3.39,P<0.001).However,the extremely rapid growth rate could not reduce the risk for emaciation/growth retardation(OR=0.68,95%CI:0.48-0.95,P>0.05). Conclusions Rapid growth rate of SGA infants will increase the risk of overweight and obesity in school-age children significantly.Early monitoring of physical development of SGA infants should be thought highly of,so that whether the growth rate of SGA children is too fast could be determined as early as possible.Thus,related prevention strategies could be made,thereby reducing the long-term risk of adverse metabolism associated with excessive growth.
Key words
full-termsmallforgestationalageinfants /
obesity /
catchingupgrowth
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