Research progress on the treatment strategy of obesity related asthma in children

SUN Liu-yu; QU Shu-qiang

doi:10.11852/zgetbjzz2018-1737

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (12) : 1317-1319. DOI: 10.11852/zgetbjzz2018-1737

Research progress on the treatment strategy of obesity related asthma in children

SUN Liu-yu,QU Shu-qiang

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Abstract

Obesity and asthma are two important pediatric diseases all over the world. With the development of economy,the incidence of these two diseases has increased dramatically in recent years. Based on the clinical experience,the phenotype of obesity related asthma is confirmed by reviewing the relevant study. The characteristics of obesity related asthma are difficult to control,severe symptoms,insensitive to inhaled glucocorticoid,frequent attacks,lower quality of life than other phenotypes. Most current studies focus on the treatment of asthma,ignoring the effects of obesity. In addition to asthma treatment,children with obesity related asthma should also lose weight to alleviate the impact of obesity on asthma. This review is aimed to explore feasible treatment strategies for obesity-associated asthma in children.

Key words

obesity / asthma / body mass indes / weight loss treatment

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SUN Liu-yu,QU Shu-qiang. Research progress on the treatment strategy of obesity related asthma in children[J]. Chinese Journal of Child Health Care. 2019, 27(12): 1317-1319 https://doi.org/10.11852/zgetbjzz2018-1737

References

[1] 刘传合,洪建国,尚云晓.中国城市儿童哮喘患病率年对比研究[J].中国实用儿科杂志,2015,30(8):596-600.
[2] 于冬梅,琚腊红,赵丽云.中国0～5岁儿童超重肥胖分布特征[J].中华流行病学杂志,2018,39(6):710-714.
[3] 房红芸,翟屹,赵丽云.中国6～17岁儿童青少年超重肥胖流行特征[J].中华流行病学杂志,2018,39(6):724-727.
[4] Forno E,Celedón JC.The effect of obesity,weight gain,and weight loss on asthma inception and control[J].Curr Opin Allergy Clin Immunol,2017,17(2):123-130.
[5] Forno E,Weiner DJ,Mullen J,et al.Obesity and airway dysanapsis in children with and without asthma[J].Am J Respir Crit Care Med,2017,195(3):314-323.
[6] Rastogi D,Holguin F.Metabolic dysregulation,systemic inflammation,and pediatric obesity-related asthma[J].Ann Am Thorac Soc,2017,14(Suppl 5):363-367.
[7] 中华医学会儿科学分会呼吸学组.儿童支气管哮喘诊断与防治指南2016年版[J].中华儿科杂志,2016,54(3):167-181.
[8] Mcgarry ME,Castellanos E,Thakur N,et al.Obesity and bro nchodilator response in black and hispanic children and adolescents with asthma[J].Chest,2015,147(6):1591-1598.
[9] Peters-Golden M,Swern A,Bird SS,et al.Influence of body mass index on the response to asthma controller agents[J].Eur Respir J,2006,27(3):495-503.
[10] Chen Z,Salam MT,Alderete TL,et al.Effects of childhood asthma on the development of obesity among school-aged children[J].Am J Respir Crit Care Med,2017,195(9):1181-1188.
[11] Vijayakanthi N,Greally JM,Rastogi D.Pediatric obesity-related asthma:the role of metabolic dysregulation[J].Pediatrics,2016,137(5):e20150812.
[12] Willeboordse M,van de Kant KDG,Tan FE,et al.A multifactorial weight reduction programme for children with overweight and asthma:a randomized controlled trial[J].PLoS One,2016,11(6):e0157158.
[13] Leinaar E,Alamian A,Wang L.A systematic review of the relationship between asthma,overweight,and the effects of physical activity in youth[J].Ann Epidemiol,2016,26(7):504-510.
[14] Holderness H,Chin N,Ossip DJ,et al.Physical activity,restrictions in activity,and body mass index among urban children with persistent asthma[J].Ann Allergy Asthma Immunol,2017,118(4):433-438.
[15] Willeboordse M,van de Kant KD,van der Velden CA,et al.Associations between asthma,overweight and physical activity in children:a cross-sectional study[J].BMC Public Health,2016,16(1):919.
[16] Diaz J,Farzan S.Clinical implications of the obese-asthma ph enotypes[J].Immunol Allergy Clin North Am,2014,34(4):739-751.
[17] Jensen ME,Gibson PG,Collins CE,et al.Diet-induced wei ght loss in obese children with asthma:a randomized controlled trial[J].Clin Exp Allergy,2013,43(7):775-784.
[18] Nagel G,Weinmayr G,Kleiner A,et al.Effect of diet on asthma and allergic sensitisation in the international Study on Allergies and Asthma in Childhood(ISAAC) Phase Two[J].Thorax,2010,65(6):516-522.
[19] Lang JE,Mougey EB,Allayee H,et al.Nutrigenetic respon se to omega-3 fatty acids in obese asthmatics(NOOA):rationale and methods[J].Contemp Clin Trials,2013,34(2):326-335.
[20] Mickleborough TD,Murray RL,Ionescu AA,et al.Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes[J].Am J Respir Crit Care Med,2003,168(10):1181-1189.
[21] Mickleborough TD,Lindley MR,Ionescu AA,et al.Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma[J].Chest,2006,129(1):39-49.
[22] Vo P,Bair-merritt M,Camargo CA.The potential role of vitamin D in the link between obesity and asthma severitycontrol in children[J].Expert Rev Respir Med,2015,9(3):309-325.
[23] Pojsupap S,Iliriani K,Sampaio TZ,et al.Efficacy of high-dose vitamin D in pediatric asthma:a systematic review and meta-analysis[J].J Asthma,2015,52(4):382-390.
[24] Tachimoto H,Mezawa H,Segawa T,et al.Improved control of childhood asthma with low-dose,short-term vitamin D supplementation:a randomized,double-blind,placebo-controlled trial[J].Allergy,2016,71(7):1001-1009.
[25] Lang JE.Obesity and asthma in children:current and future therapeutic options[J].Paediatr,2014,16(3):179-188.
[26] Styne DM,Arslanian SA,Connor EL,et al.Response to letter pediatric obesity-assessment,treatment,and prevention an endocrine society clinical practice guideline[J].J Clin Endocrinol Metab,2017,102(6):2123-2124.