Objective To investigate the correlation between human plasma antimicrobial peptides LL-37 and 25-(OH)D3 and recurrent upper respiratory tract infections in children,in order to provide evidence for the prevention and treatment of recurrent upper respiratory tract infections.Methods Totally 24 children with repeated upper respiratory tract infection in the Affiliated Hospital of Hebei University from February to August in 2018 were enrolled in experimental group,and 24 healthy children in the same period were selected as control group.Blood samples were taken from both groups on an empty stomach to detect plasma LL-37 and 25-hydroxyvitamin D3 levels,and the times for upper respiratory tract infections in children with repeated respiratory infections were recorded. Results The plasma level of 25-(OH)D3 and antibacterial peptide LL-37 in experimental group were significantly lower than those in healthy controls[25-(OH)D3 : (18.37±5.50) ng/ml vs.(29.24±9.04) ng/ml,LL-37: (3.45±0.98) ng/ml vs.(8.93±2.23) ng/ml,P<0.05)].The plasma level of 25-(OH)D3 and LL-37 were negatively related to the times for upper respiratory tract infections(r=-0.645,-0.560,P<0.05),and the level of 25-(OH)D3 was positively correlated with LL-37(r=0.908,P<0.05). Conclusions Vitamin D deficiency is associated with recurrent upper respiratory tract infections.Plasma LL-37 level decreases in children with repeated upper respiratory tract infections,and 25-(OH)D3 deficiency may be an important cause of decreasing level of plasma LL-37 in children with repeated upper respiratory tract infections.
Key words
recurrent respiratory tract infection /
antimicrobial peptides /
LL-37 /
vitamin D
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References
[1] 林罗娜,林立,李昌崇.Cathelicidin LL-37表达调节机制研究现状[J].国际呼吸杂志,2015,35(17):1352-1356.
[2] 王永东.抗菌肽LL-37的研究进展[J].国际免疫学杂志,2007,30(1):47-51.
[3] 中国医师协会儿科医师分会过敏专业委员会,中华医学会儿科学分会呼吸学组,中国医师协会儿科医师分会风湿免疫专业委员会,等.反复呼吸道感染临床诊治路径[J].中国实用儿科杂志,2016,31(10):721-725.
[4] Xuguang ZHANG,Fengshu DING,Huaining LI,et al.Low serum levels of vitamins A,D and E are associated with recurrent reapiratory tract infections in children living in northern china:a case control study[J].PLoS One,2016,doi:10.1371/journal.pone.0167689.
[5] 李亚,聂鑫,崔明明.儿童反复呼吸道感染与血清维生素A、D、E水平的相关性研究[J].中国儿童保健杂志,2017,25(6):634-636.
[6] 丁静,王玉芝,沈娟,等.抗菌肽LL-37对耐甲氧西林金黄色葡萄球菌生物膜的抑制作用[J].广东药学院学报,2016,32(4):498-502.
[7] 史鹏伟,高艳彬,卢志阳,等.抗菌肽LL-37对鲍曼不动杆菌生物膜的抑制作用[J].南方医科大学学报,2014,34(3):426-429.
[8] 霍彦,王芳,孙蓓,等.抗菌肽LL-37的原核表达纯化及对假丝酵母菌的抑制作用[J].中华妇产科杂志,2016,51(2):120-125.
[9] Kyung KS,Park S,Eun-So LEE.Toll-like receptors and antimicrobial peptides expressions of psoriasis:correlation with serum vitamin D level[J].J Korean Med Sci,2010,25:1506-1512.
[10] 张晓丹,赵贝,李光慧,等.维生素D缺乏与感染发生的相关性及其机制研究进展[J].中国药房,2018,29(5):710-715.
[11] Alexandra LJ,Yamshchikov V,Judd SE.Alterations in vitamin D status and anti-microbial peptide levels in patients in the intensive care unit with sepsis[J].Transl Med,2009,7:28.
[12] Martineau AR,Wilkinson KA,Newton SM,et al.IFN and TNF-independent vitamin D-inducible human suppression of mycobacteria:the role of cathelicidin LL-37[J].Immunol,2007,178:7190-7198.
[13] Kanda N,Hau CS,Tada Y,et al.Decreased serum LL-37 and vitamin D3 levels in atopic dermatitis:relationship between IL-31 and oncostatin M[J].Allergy,2012.doi:10.1111/j.1398-9995.2012.02824.x.
[14] van der Does AM,Bergman P,Agerberth B,et al.Induction of the human cathelicidin LL-37 as a novel treatment against bacterial infections[J].J Leukoc Biol,2012,92: 735-742.
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