Research advance on feeding difficulties of Prader-Willi syndrome in infants

LIAN Wen-jun; DUAN Pei; LIANG Rui-xing; NIU Dong-he; LU Xiang-peng; ZHENG Hong

doi:10.11852/zgetbjzz2018-1533

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Chinese Journal of Child Health Care ›› 2019, Vol. 27 ›› Issue (3) : 273-276. DOI: 10.11852/zgetbjzz2018-1533

Research advance on feeding difficulties of Prader-Willi syndrome in infants

LIAN Wen-jun¹,DUAN Pei¹,LIANG Rui-xing¹,NIU Dong-he¹,LU Xiang-peng²,ZHENG Hong²

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Abstract

Objective Prader-Willi syndrome(PWS) is a genetic disease caused by imprinting genetic defects,which is accompanied by problems such as central hypotonia,feeding difficulties and progressive obesity. Nutritional problems caused by feeding difficulties are one of the causes of infant mortality in PWS children. This review summarizes the reasons of feeding difficulties in infants and young children with PWS and the methods of improving feeding. All the evidence that the dysfunction of chromosomal deficiencies in PWS children and the change of the level of hunger hormones in children are the main causes of feeding difficulty. Intranasal infusion of oxytocin,subcutaneous injection of growth hormone,oral exercise and nasogastric feeding tube feeding method can help infants and young children with PWS feeding difficulties,thereby improving nutritional status.

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Prader-Willi syndrome / feeding difficulties / hypotonia

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LIAN Wen-jun,DUAN Pei,LIANG Rui-xing,NIU Dong-he,LU Xiang-peng,ZHENG Hong. Research advance on feeding difficulties of Prader-Willi syndrome in infants[J]. Chinese Journal of Child Health Care. 2019, 27(3): 273-276 https://doi.org/10.11852/zgetbjzz2018-1533

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