Objective To study the clinical security of sustained lung inflation(SLI) in neonatal respiratory distress syndrome(NRDS) for preterm neonates,in order to provide evidence for clinical treatment. Methods A total of 80 NRDS infants in Dongguan Maternal and Child Health Care Hospital were enrolled in this study from May 2017 to September 2018,and were randomly divided into control group and experimental group,with 40 cases in each group.The experimental group received SLI after intubation,and then pulmonary surfactant prolonged the process of intubate-surfactant-extubate(INSURE).While the control group was given INSURE under the failure of nasal continuous positive airway pressure(nCPAP).The clinical treatment efficacy and complications,including intracranial hemorrhage,pulmonary air leakage,bronchopulmonary dysplasia(BPD),retinopathy of prematurity(ROP),patent ductus arteriosus(PDA),neonatal necrotizing entercolitis(NEC),were compared between the two groups. Results The cases of the success of nCPAP within 72 hours after birth in experimental group was more than that in control group(P=0.021),and the time for invasive mechanical ventilation of experimental group was significantly shorter than that in control group(P=0.038).There were no statistically significant differences on the incidence of intracranial hemorrhage,pulmonary leakage,BPD,ROP,PDA,NEC and mortality between the two groups(P>0.05).The time effect on the change of blood gas indexes including pH,PaO2,PCO2 and BE of the two groups was significant(P＜0.05),while the intervention effect was not significant(P>0.05). Conclusion SLI as a treatment for NRDS,can reduce the invasive mechanical ventilation rate and shorten the invasive mechanical ventilation time within 72 hours after birth,whereas it does not increase the incidence of pulmonary air leakage,intracranial hemorrhage,BPD,ROP,PDA,NEC and other complications.
Key words
sustained lung inflation /
neonatal respiratory distress syndrome /
preterm infants /
security
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